Development of novel transition metal-catalyzed synthetic approaches for the synthesis of a dihydrobenzofuran nucleus: a review

• Published in: RSC advances Vol. 14; no. 21; pp. 14539 - 14581
• Main Authors: Ashraf, Rabia, Zahoor, Ameer Fawad, Ali, Kulsoom Ghulam, Nazeer, Usman, Saif, Muhammad Jawwad, Mansha, Asim, Chaudhry, Aijaz Rasool, Irfan, Ahmad
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 02.05.2024
• Subjects: Chemical synthesis; Scaffolds; Transition metals
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d4ra01830c

The synthesis of dihydrobenzofuran scaffolds bears pivotal significance in the field of medicinal chemistry and organic synthesis. These heterocyclic scaffolds hold immense prospects owing to their significant pharmaceutical applications as they are extensively employed as essential precursors for constructing complex organic frameworks. Their versatility and importance make them an interesting subject of study for researchers in the scientific community. While exploring their synthesis, researchers have unveiled various novel and efficient pathways for assembling the dihydrobenzofuran core. In the wake of extensive data being continuously reported each year, we have outlined the recent updates (post 2020) on novel methodological accomplishments employing the efficient catalytic role of several transition metals to forge dihydrobenzofuran functionalities. The dihydrobenzofuran scaffolds demonstrate a wide range of biological activities. Several transition metals have been employed as catalysts for the efficacious synthesis of these structurally important frameworks.