Disseminated Anaplastic Lymphoma Kinase (ALK)-Positive T-cell Lymphoma Involving the Uterus and Cervix: A Case Report

Primary or secondary non-Hodgkin lymphomas (NHLs) involving the female gynecologic tract are rare. T-cell subtypes are further rare and portend a worse prognosis. We present a case of a 23-year-old female presenting with a cervical mass accompanied by constitutional symptoms and abnormal vaginal ble...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 1; p. e52815
Main Authors Yang, Erin J, Sabri, Ahmed, Awad, Seifeldin, Conrad, Lesley B, Cantu, David
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 23.01.2024
Cureus
Subjects
Antigens
Biopsy
Bone marrow
Case reports
Cells
Cervix
Chemotherapy
Cysts
Cytokeratin
Disease
Emergency medical care
Endometrium
Females
Fractures
Hemoglobin
Kinases
Magnetic resonance imaging
Medical prognosis
Melanoma
Metastasis
Morphology
Obstetrics/Gynecology
Oncology
Pathology
Sarcoma
Stains & staining
Ultrasonic imaging
Uterus
Vagina
gynecology
alk-positive
non-hodgins lymphoma
disseminated disease
immunohistochemistry
t-cell lymphoma
adult t-cell lymphoma
rare cancers
abnormal uterine bleeding
rare metastases
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Summary:Primary or secondary non-Hodgkin lymphomas (NHLs) involving the female gynecologic tract are rare. T-cell subtypes are further rare and portend a worse prognosis. We present a case of a 23-year-old female presenting with a cervical mass accompanied by constitutional symptoms and abnormal vaginal bleeding. Immunohistochemistry studies revealed the presence of disseminated T-cell non-Hodgkin lymphoma that was anaplastic lymphoma kinase (ALK)-positive. The patient demonstrated a complete response to systemic chemotherapy initially and again after the relapse of the disease one year after diagnosis. To our knowledge, this is the first case of an ALK-positive T-cell lymphoma with secondary involvement of the uterus and cervix; all previously published cases of this histologic subtype in the gynecologic tract describe primary disease of the vagina. This case emphasizes the importance of immunohistochemistry studies inclusive of T-cell and B-cell markers when evaluating biopsies from cervical tumors to render the appropriate diagnosis and guide systemic therapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.52815