Resveratrol induces apoptosis in pancreatic cancer cells

• Published in: Chinese medical journal Vol. 124; no. 11; pp. 1695 - 1699
• Main Authors: Zhou, Jia-Hua, Cheng, Hai-Yan, Yu, Ze-Qian, He, Dao-Wei, Pan, Zheng, Yang, De-Tong
• Format: Journal Article
• Language: English
• Published: China Department of Biliary-Pancreatic Surgery, Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China%Medicine School of Southeast University, Nanjing, Jiangsu 210009, China 05.06.2011
• Subjects: Apoptosis - drug effects; Blotting, Western; Caspase 3 - metabolism; Cell Survival - drug effects; Humans; Mitogen-Activated Protein Kinases - metabolism; Pancreatic Neoplasms - metabolism; Stilbenes - pharmacology; Tumor Cells, Cultured; 免疫印迹分析; 毒性测试; 癌症治疗; 白藜芦醇; 细胞凋亡; 胰腺癌; 胰腺细胞; 诱导; apoptosis; gene therapy; pancreatic cancer; resveratrol
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.11.017

Background Pancreatic cancer is one of the most lethal human cancers with a very low survival rate of 5 years. Conventional cancer treatments including surgery, radiation, chemotherapy or combinations of these show little effect on this disease. Several proteins have been proved critical to the development and the progression of pancreatic cancer. The aim of this study was to investigate the effect of resveratrol on apoptosis in pancreatic cancer cells. Methods Several pancreatic cancer cell lines were screened by resveratrol, and its toxicity was tested by normal pancreatic cells. Western blotting was then performed to analyze the molecular mechanism of resveratrol induced apoptosis of pancreatic cancer cell lines.