Comparision of high sensitivity C-reactive protein and matrix metalloproteinase 9 in patients with unstable angina between with and without significant coronary artery plaques

• Published in: Chinese medical journal Vol. 124; no. 11; pp. 1657 - 1661
• Main Authors: Wang, Li-Xin, Lü, Shu-Zheng, Zhang, Wei-Jun, Song, Xian-Tao, Chen, Hui, Zhang, Li-Jie
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China%Institute of Biomedical Engineering, Capital Medical University, Beijing 100069, China 05.06.2011
• Subjects: Aged; Angina, Unstable - blood; Angina, Unstable - metabolism; Angina, Unstable - physiopathology; C-Reactive Protein - metabolism; Coronary Angiography; Coronary Artery Disease - blood; Coronary Artery Disease - metabolism; Coronary Artery Disease - physiopathology; Coronary Vessels - metabolism; Coronary Vessels - pathology; C反应蛋白; Female; Humans; Male; Matrix Metalloproteinase 9 - blood; Middle Aged; Multivariate Analysis; Risk Factors; Smoking - adverse effects; 不稳定型; 冠状动脉疾病; 基质金属蛋白酶; 心绞痛; 患者; 斑块; 高灵敏度; high sensitivity C-reactive protein; unstable angina; coronary artery stenosis; matrix metalloproteinase 9; angiography
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.11.010

Background Inflammation within vulnerable coronary plaques may cause unstable angina by promoting rupture and erosion. C-reactive protein （CRP） is the most reliable and accessible test method for clinical use for identifying coronary artery disease event. Matrix metalloproteinase 9 （MMP-9） is highly over-expressed in the vulnerable regions of a plaque. Our aim was to evaluate the plasma levels of MMP-9 and hsCRP in subjects with both unstable angina and coronary plaques, as well as in those with unstable angina without coronary plaques.