Is comparative cardiotoxicity of S(-) and R(+) bupivacaine related to enantiomer-selective inhibition of L-type Ca2+ channels?

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Bibliographic Details
Published inAnesthesia and analgesia Vol. 92; no. 2; pp. 496 - 501
Main Authors ZAPATA-SUDO, Gisele, TRACHEZ, Margarete M, SUDO, Roberto T, NELSON, Thomas E
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott 01.02.2001
Subjects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Medical sciences
Pharmacology. Drug treatments
Toxicity: cardiovascular system
Heart
Rat
Toxicity
Rodentia
Cardiovascular disease
Ionic channel
In vitro
Local anesthetic
Stereoselectivity
Vertebrata
Mammalia
Bupivacaine
Calcium ion
Animal
Enantiomer
Organic amide
Mechanism of action
Anilide
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More Information
ISSN:0003-2999
1526-7598
DOI:10.1097/00000539-200102000-00040