Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc] − , enable significantly enhanced solubilisation...

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Bibliographic Details
Published inRSC advances Vol. 6; no. 109; pp. 107214 - 107218
Main Authors Cunningham, Richard, Forero-Martinez, Nancy C., Hardacre, Christopher, Youngs, Tristan G. A., Migaud, Marie E.
Format Journal Article
LanguageEnglish
Published 2016
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Summary:Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc] − , enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA23078D