Homogeneous Iron‐Catalysed Oxidation Of Non‐Activated Alkanes With Hydrogen Peroxide

A novel synthetic protocol for the direct oxidation of alkanes, including cyclic and linear ones, to give ketones and alcohols using hydrogen peroxide as terminal oxidant under ambient conditions is presented. The active catalyst for this challenging transformation is conveniently generated by combi...

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Bibliographic Details
Published inChemCatChem Vol. 15; no. 19
Main Authors Mao, Shuxin, Verspeek, Dennis, Wen, Xiaodong, Yang, Yong, Li, Yong‐Wang, Junge, Kathrin, Beller, Matthias
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 06.10.2023
Subjects
Alcohols
Alkanes
Hydrogen peroxide
Iron
Ketones
Oxidation
Oxidizing agents
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Summary:A novel synthetic protocol for the direct oxidation of alkanes, including cyclic and linear ones, to give ketones and alcohols using hydrogen peroxide as terminal oxidant under ambient conditions is presented. The active catalyst for this challenging transformation is conveniently generated by combination of simple Fe salts with N‐methyl bis(picolylamine) (Me‐bpa). Utilizing picolinic acid as additive leads to improved yields of ketones and alcohols (32‐57 %). The reaction can be conveniently scaled up to multi‐g scale.
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ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.202300735