Complex Antiplatelet Therapy Management in Patients Requiring Urgent Interventions for Pseudoachalasia and Esophageal Obstruction
This case report describes the use of intravenous (IV) cangrelor as a transient tool for antiplatelet bridging therapy in a 70-year-old male with coronary artery disease and esophageal strictures who underwent recent percutaneous coronary intervention (PCI) and subsequently required a pre-oral endos...
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| Published in | Curēus (Palo Alto, CA) Vol. 16; no. 3; p. e57209 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cureus Inc
29.03.2024
Cureus |
| Subjects | |
| Online Access | Get full text |
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| Abstract | This case report describes the use of intravenous (IV) cangrelor as a transient tool for antiplatelet bridging therapy in a 70-year-old male with coronary artery disease and esophageal strictures who underwent recent percutaneous coronary intervention (PCI) and subsequently required a pre-oral endoscopic myomectomy (POEM) procedure. The patient was switched from oral clopidogrel to IV cangrelor drip prior to the procedure, which was successful in preventing stent thrombosis. The case highlights the potential benefits of IV antiplatelet therapy in patients unable to tolerate oral medications in the setting of esophageal obstructions following recent coronary stent placement in a critical care setting. |
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| AbstractList | This case report describes the use of intravenous (IV) cangrelor as a transient tool for antiplatelet bridging therapy in a 70-year-old male with coronary artery disease and esophageal strictures who underwent recent percutaneous coronary intervention (PCI) and subsequently required a pre-oral endoscopic myomectomy (POEM) procedure. The patient was switched from oral clopidogrel to IV cangrelor drip prior to the procedure, which was successful in preventing stent thrombosis. The case highlights the potential benefits of IV antiplatelet therapy in patients unable to tolerate oral medications in the setting of esophageal obstructions following recent coronary stent placement in a critical care setting. |
| Author | Hernandez, Oscar L Bvute, Kushinga Vallejo, Charles |
| AuthorAffiliation | 1 Internal Medicine, Florida Atlantic University, Boca Raton, USA |
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| Author_xml | – sequence: 1 givenname: Charles surname: Vallejo fullname: Vallejo, Charles organization: Internal Medicine, Florida Atlantic University, Boca Raton, USA – sequence: 2 givenname: Kushinga surname: Bvute fullname: Bvute, Kushinga organization: Internal Medicine, Florida Atlantic University, Boca Raton, USA – sequence: 3 givenname: Oscar L surname: Hernandez fullname: Hernandez, Oscar L organization: Internal Medicine, Florida Atlantic University, Boca Raton, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38681452$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1055/s-0040-1721504 10.1161/CIRCULATIONAHA.106.618066 10.1136/neurintsurg-2020-015841 10.4244/EIJV9I2A35 |
| ContentType | Journal Article |
| Copyright | Copyright © 2024, Vallejo et al. Copyright © 2024, Vallejo et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2024, Vallejo et al. 2024 Vallejo et al. |
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| Keywords | gastroenterology and endoscopy cangrelor antiplatelet therapy plavix primary percutaneous coronary intervention (pci) |
| Language | English |
| License | Copyright © 2024, Vallejo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| References | Alshawabkeh LI (ref1) 2013; 9 Rossini R (ref2) 2020; 4 Spertus JA (ref3) 2006; 113 Linfante I (ref4) 2021; 13 |
| References_xml | – volume: 4 year: 2020 ident: ref2 article-title: Antiplatelet therapy with cangrelor in patients undergoing surgery after coronary stent implantation: a real-world bridging protocol experience publication-title: TH Open doi: 10.1055/s-0040-1721504 contributor: fullname: Rossini R – volume: 113 year: 2006 ident: ref3 article-title: Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.618066 contributor: fullname: Spertus JA – volume: 13 year: 2021 ident: ref4 article-title: Intravenous cangrelor and oral ticagrelor as an alternative to clopidogrel in acute intervention publication-title: J Neurointerv Surg doi: 10.1136/neurintsurg-2020-015841 contributor: fullname: Linfante I – volume: 9 year: 2013 ident: ref1 article-title: Outcomes of a preoperative "bridging" strategy with glycoprotein IIb/IIIa inhibitors to prevent perioperative stent thrombosis in patients with drug-eluting stents who undergo surgery necessitating interruption of thienopyridine administration publication-title: EuroIntervention doi: 10.4244/EIJV9I2A35 contributor: fullname: Alshawabkeh LI |
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| SubjectTerms | Cardiology Cardiovascular disease Endoscopy Esophagus Gastroenterology Internal Medicine Oral administration Patients Stents Surgery Thrombosis |
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| Title | Complex Antiplatelet Therapy Management in Patients Requiring Urgent Interventions for Pseudoachalasia and Esophageal Obstruction |
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