A novel, fast and efficient one-pot four-component procedure for preparation of some alkyl spiro[indeno[1,2-b]quinoxaline-11,3′-pyrrolizine]-2′-carboxylates

In this study we report a novel one-pot reaction which stereoselectively affords alkyl spiro[indeno[1,2- b ]quinoxaline-11,3′- pyrrolizine]-2′-carboxylates via the four-component condensation of ninhydrin, phenylenediamines, proline, and acrylic acid derivatives. The reactions were run in ethanol an...

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Bibliographic Details
Published inJournal of the Iranian Chemical Society Vol. 7; no. 1; pp. 45 - 50
Main Authors Karsalary, A. Alizadeh, Mohammadizadeh, M. R., Hasaninejad, A. R., Mohammadi, A. A., Karimi, A. R.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.03.2010
Subjects
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Proline
Alkyl acrylates
Ninhydrin
Phenylenediamines
quinoxaline-11,3′-pyrrolizine]-2′-carboxylates
Alkyl spiro[indeno[1,2
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Summary:In this study we report a novel one-pot reaction which stereoselectively affords alkyl spiro[indeno[1,2- b ]quinoxaline-11,3′- pyrrolizine]-2′-carboxylates via the four-component condensation of ninhydrin, phenylenediamines, proline, and acrylic acid derivatives. The reactions were run in ethanol and completed at less than 25 min and the products were obtained in very good yields. The stereochemistry of the products was deduced on the basis of the 1 H NOESY and comparison with the related systems.
ISSN:1735-207X
1735-2428
DOI:10.1007/BF03245858