Influence of Soy Isoflavone on Lindane Cumulant in Sprague-Dawley Rats

• Published in: Biomedical and environmental sciences Vol. 27; no. 8; pp. 637 - 640
• Main Authors: Yang, Yang, Zhang, Yun Bo, Sheng, Wei, Fu, Zheng Hai, Wang, Zhe, Wang, Xiao, Guan, Si Yuan, Na, Xiao Lin
• Format: Journal Article
• Language: English
• Published: China Department of Environmental Hygiene, Public Health college, Harbin Medical University, Harbin 150086, Heilongjiang, China%Department of Chemistry, Zhejiang University, Hangzhou 310058, Zhejiang, China 01.08.2014
• Subjects: Animals; Brain - metabolism; Estradiol - blood; Female; Glycine max - chemistry; Hexachlorocyclohexane - pharmacology; Isoflavones - pharmacology; Rats; Rats, Sprague-Dawley; SD大鼠; Testosterone - blood; Uterus - drug effects; 大豆异黄酮; 子宫; 林丹; 清水; 累积量; 雌二醇
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2014.097

Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat＇s body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat＇s uterus.