Treatment of Refractory Ischemic Priapism: A Case Report and Literature Review

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 6; p. e39882
• Main Authors: Vazquez Gonzalez, Jose Rogelio, Cortez Betancourt, Roberto, Alvarez Lopez, Jose Gerardo, Cortez Ramirez, David, Garcia Rivera, Oscar Uriel
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 02.06.2023; Cureus
• Subjects: Acidosis; Case reports; Emergency medical care; Erectile dysfunction; Gases; Genital diseases; Hypoxia; Ischemia; Neurological disorders; Pain; Penis; Public health; Sickle cell anemia; Trauma; Urology; Veins & arteries; ischemic priapism; priapism refractory to treatment; surgical treatment of ischemic priapism; high flow; medical treatment of ischemic priapism; low flow; recurrent priapism; erectile dysfunction; priapism; stuttering priapism
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.39882

Recurrent priapism is a rare and poorly known entity. It is defined by recurrent episodes of painful erections that last less than four hours. The etiology is similar to that of ischemic priapism. Episodes lasting more than four hours require immediate intervention to prevent penile fibrosis and subsequent erectile dysfunction. A 42-year-old male with no significant chronic-degenerative history was referred to our medical center from his second-level medical unit after a 56-hour history of ischemic priapism with the persistence of tumescence despite medical and surgical treatment. Upon interrogation, the patient reported stuttering (recurrent) episodes of painful erections lasting approximately three to four hours, not associated with sexual activity or arousal, in the past two years, with spontaneous resolution. He denied the use of psychotropics or drugs for erectile dysfunction. As a palliative measure, a left saphenous-cavernous (Grayhack) bypass was performed, with a 90% decrease in tumescence and total resolution of pain during the first 12 hours. There is little information and treatment recommendations for patients with recurrent priapism, and even less for patients who are refractory to conventional medical and surgical treatment. Recurrent or stuttering priapism is a condition with a low incidence and a pathophysiology compatible with low-flow priapism. It is difficult to treat and has a poor prognosis in terms of erectile function. Likewise, it is mostly associated with the use of psychotropic drugs such as cocaine and marijuana, medications for erectile dysfunction such as phosphodiesterase inhibitors, prostaglandin E1 analogues, and hematological malignancies such as sickle cell anemia and multiple myeloma. The aim of this article is to share our experience with a patient refractory to multiple medical and surgical treatments.