A highly efficient michael addition of indoles to α,β-unsaturated electron-deficient compounds in acidic SDS micellar media

The Michael addition of indoles to α,β -unsaturated electron deficient compounds was catalyzed efficiently at room temperature in acidic micellar solution of sodium dodecyl sulfate (SDS). The substitution on the indole nucleus occurred exclusively at the 3-position in good to excellent yields, and n...

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Bibliographic Details
Published inJournal of the Iranian Chemical Society Vol. 6; no. 3; pp. 588 - 593
Main Authors Jafari, A. A., Moradgholi, F., Tamaddon, F.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.09.2009
Subjects
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Michael addition
Micellar media
Indole
Unsaturated electron-deficient compounds
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Summary:The Michael addition of indoles to α,β -unsaturated electron deficient compounds was catalyzed efficiently at room temperature in acidic micellar solution of sodium dodecyl sulfate (SDS). The substitution on the indole nucleus occurred exclusively at the 3-position in good to excellent yields, and no N-alkylation products were observed.
ISSN:1735-207X
1735-2428
DOI:10.1007/BF03246538