Mammalian Cell Cycles without Cyclin E-CDK2

The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle...

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Bibliographic Details
Published inCell cycle (Georgetown, Tex.) Vol. 3; no. 3; pp. 290 - 293
Main Authors Yu, Qunyan, Sicinski, Piotr
Format Journal Article
LanguageEnglish
Published Taylor & Francis 01.03.2004
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
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Summary:The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle progression of normal, nontransformed cells and of cancer cells. Several recent reports challenge this notion.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.3.3.709