18F-FDG PET/CT in Graft Versus Host Disease-Associated Polymyositis

Graft versus host disease (GVHD) is the most frequent and serious complication of allogenic hematopoietic stem cell transplant. Polymyositis is a rare neuromuscular manifestation of GVHD, which often responds well to corticosteroid and immunosuppression therapy. We present a case of a 38-year-old ma...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 45; no. 2; p. e106
Main Authors Sood, Apurva, Khadwal, Alka Rani, Lukose, Tinu, Kumar, Rajender, Singh, Harmandeep, Bal, Amanjit, Mittal, Bhagwant Rai
Format Journal Article
LanguageEnglish
Published United States 01.02.2020
Subjects
Adult
Fluorodeoxyglucose F18
Graft vs Host Disease - complications
Graft vs Host Disease - diagnostic imaging
Humans
Male
Polymyositis - diagnostic imaging
Polymyositis - etiology
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
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Summary:Graft versus host disease (GVHD) is the most frequent and serious complication of allogenic hematopoietic stem cell transplant. Polymyositis is a rare neuromuscular manifestation of GVHD, which often responds well to corticosteroid and immunosuppression therapy. We present a case of a 38-year-old man with a known case of mixed-phenotype acute leukemia after hematopoietic stem cell transplant presenting with GVHD-associated polymyositis. F-FDG PET/CT done in this case not only helped in the detection of the muscle involvement but also helped in obtaining precise muscle sample for histopathological diagnosis using PET-guided biopsy.
ISSN:1536-0229
DOI:10.1097/rlu.0000000000002818