Novel treatments in optic pathway gliomas

Optic pathway gliomas (OPG) are primary tumors of the optic nerve, chiasm, and/or tract that can be associated with neurofibromatosis type 1 (NF1). OPG generally have a benign histopathology, but a variable clinical course. Observation is generally recommended at initial diagnosis if vision is stabl...

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Published inFrontiers in ophthalmology Vol. 2; p. 992673
Main Authors Maheshwari, Akash, Pakravan, Mohammad, Charoenkijkajorn, Chaow, Beres, Shannon J, Lee, Andrew G
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2022
Subjects
Ophthalmology
stereotactic radiation
immunotherapy
bevacizumab
BRAF inhibitor
MEK inhibitor
chemotherapy
optic pathway glioma
low grade glioma
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Summary:Optic pathway gliomas (OPG) are primary tumors of the optic nerve, chiasm, and/or tract that can be associated with neurofibromatosis type 1 (NF1). OPG generally have a benign histopathology, but a variable clinical course. Observation is generally recommended at initial diagnosis if vision is stable or normal for age, however, treatment may include chemotherapy, radiotherapy, or surgery in select cases. This manuscript reviews the literature on OPG with an emphasis on recent developments in treatment.
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SourceType-Scholarly Journals-1
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This article was submitted to Neuro-Ophthalmology Disorders, a section of the journal Frontiers in Ophthalmology
Reviewed by: Tonse Ashwini Kini, University of Kentucky, United States; Mangayarkarasi Thandampallayam, University of Kentucky, United States; Nagham Al-Zubidi, University of Texas MD Anderson Cancer Center, United States
Edited by: Bayan Al Othman, University of Rochester, United States
ISSN:2674-0826
2674-0826
DOI:10.3389/fopht.2022.992673