Plasma marker based hepatoprotective evaluation of some novel synthesized benzofluorenone analogues: A medicinal chemistry approach

In an extensive search program towards development of new hepatoprotective agents, a series of novel benzofluorenones have been synthesized. These newly synthesized benzofluorenone derivatives exhibited protection against carbon tetrachloride (CCl4)-induced hepatotoxicity. This activity was estimate...

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Published inKarbala International Journal of Modern Science Vol. 3; no. 1; pp. 39 - 45
Main Authors Lambat, Trimurti L., Deo, Sujata S., Butle, Ashwin B.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2017
Subjects
Aspartate aminotransferase
Benzofluorenones
Hepatoprotective activity
Serum alanine transferase
Serum alkaline phosphatase
Hepatoprotective activity
Serum alanine transferase
Serum alkaline phosphatase
Aspartate aminotransferase
Benzofluorenones
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Summary:In an extensive search program towards development of new hepatoprotective agents, a series of novel benzofluorenones have been synthesized. These newly synthesized benzofluorenone derivatives exhibited protection against carbon tetrachloride (CCl4)-induced hepatotoxicity. This activity was estimated by levels of biochemical parameters such as aspartate aminotransferase (AST), serum alanine transferase (ALT), serum alkaline phosphatase (SALP) and total proteins (TP) carried out by using regular assay kits. [Display omitted]
ISSN:2405-609X
DOI:10.1016/j.kijoms.2017.02.002