18F-THK5351 PET Can Identify Astrogliosis in Multiple Sclerosis Plaques

A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 accumulations corresponded anatomically to MS pla...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 45; no. 2; p. e98
Main Authors Ishibashi, Kenji, Miura, Yoshiharu, Hirata, Kosei, Toyohara, Jun, Ishii, Kenji
Format Journal Article
LanguageEnglish
Published United States 01.02.2020
Subjects
Adult
Aminopyridines
Female
Gliosis - diagnostic imaging
Humans
Multiple Sclerosis - diagnostic imaging
Positron-Emission Tomography
Quinolines
Radiopharmaceuticals
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Summary:A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 accumulations corresponded anatomically to MS plaques identified by MRI. Because F-THK5351 binds to monoamine oxidase B highly expressed in astrocytes, F-THK5351 accumulates in lesions undergoing astrogliosis. Hence, elevated uptake of F-THK5351 in the present case can represent ongoing astrogliosis in inactive MS lesions (plaques).
ISSN:1536-0229
DOI:10.1097/rlu.0000000000002751