Synthesis of 3-alkoxy- and 3-alkylamino-2-alkyl-3-arylisoindolinones

Solvent-controlled regioselectivity in the reactions of 3-chloroisoindolinones with primary amines allows the rational synthesis of isoindolinones by a route suitable for parallel combinatorial chemistry.

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Bibliographic Details
Published inSynlett pp. 997 - 999
Main Authors Kitching, MS, Clegg, W, Elsegood, MRJ, Griffin, RJ, Golding, BT
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.1999
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
regioselectivity
(ACYLOXY)ALKYL ALPHA-HALIDES
combinatorial synthesis
3-HYDROXYISOINDOLIN-1-ONES
PRODUCT DISTRIBUTION
solvent effect
NUCLEOPHILICITY
isoindolinones
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Summary:Solvent-controlled regioselectivity in the reactions of 3-chloroisoindolinones with primary amines allows the rational synthesis of isoindolinones by a route suitable for parallel combinatorial chemistry.
ISSN:0936-5214
DOI:10.1055/s-1999-3116