Selective activation, different branching and grafting of poly(propylenimine)-dendrimers

Each branch of different generations of poly(propylenimine)-dendrimers is selectively bifunctionalized by easily accessible reagents. Sulfonic acid chlorides react readily with terminal primary amino groups of this dendrimer type in high yields. The sulfonamide dendrimers purely obtained in this way...

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Bibliographic Details
Published inSynlett no. 5; pp. 546 - 549
Main Authors Archut, A, Gestermann, S, Hesse, R, Kauffmann, C, Vogtle, F
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.05.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
cascade molecules
sulfonamides
multibranched compounds
dendrimers
COMPLEXES
N-alkylation
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Summary:Each branch of different generations of poly(propylenimine)-dendrimers is selectively bifunctionalized by easily accessible reagents. Sulfonic acid chlorides react readily with terminal primary amino groups of this dendrimer type in high yields. The sulfonamide dendrimers purely obtained in this way reveal a considerable synthetic potential. The substitution of the sulfonamide proton of each branch by means of alkyl and benzyl halides, respectively, can be used for a second multiple functionalization. Other convergently synthesized dendrons are grafted on by alkylation of such oligo sulfonamide dendrimers using dendritic halides resulting in structure perfect difunctionalized dendrimers.
ISSN:0936-5214
DOI:10.1055/s-1998-1691