Effects of Zaldaride Maleate, an Antidiarrheal Compound, on Intracellular Ca2+-Mediated Short-Circuit Current Response in the Rat Colonic Mucosa

• Published in: Japanese journal of pharmacology Vol. 83; no. 1; pp. 86 - 88
• Main Authors: Aikawa, Nobuo, Karasawa, Akira, Ohmori, Kenji
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 2000
• Subjects: Calmodulin; Short-circuit current(Isc); Zaldaride maleate
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.83.86

The effect of zaldaride maleate(ZAL)on intracellular Ca2+−mediated short−curcuit current(Isc)response in rat colonic mucosa was investigated.The Isc response to acetylcholine was partially reduced by the neuronal blocker tetrodotoxin.The tetrodotoxin−sensitive Isc response to acetylcholine was inhibited by ZAL.The tetrodotoxin−insensitive effect, which indicates direct stimulation of acetylcholine in colonic mucosa, was not affected by ZAL.The Isc response to the Ca2+ ionophore A23187 was reduced by ZAL in the presence of tetrodotoxin.These results suggest that ZAL reduces colonic ion secretion by inhibiting a tetrodotoxin−sensitive neuronal pathway and an intracellular Ca2+ pathway in epithelium.