Prognostic Factors of Human Immunodeficiency Virus-Infected Patients on Chronic Hemodialysis

• Published in: Blood purification Vol. 44; no. 3; pp. 244 - 250
• Main Authors: Laranjinha, Ivo, João Matias, Patrícia, Dickson, Jorge, Estibeiro, Hermínia, Boquinhas, Helena, Barata, José Diogo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2017
• Subjects: Adult; Aged; Disease-Free Survival; Female; Follow-Up Studies; HIV Infections - mortality; HIV Infections - therapy; HIV-1; Humans; Male; Middle Aged; Original Article; Renal Dialysis; Retrospective Studies; Sex Factors; Survival Rate; Human immunodeficiency virus infection; Hemodialysis; Survival
• ISSN: 0253-5068; 1421-9735
• DOI: 10.1159/000478966

Background/Aims: The number of human immunodeficiency virus (HIV)-infected patients on hemodialysis (HD) have increased, and their prognostic factors are still poorly clarified. The study aimed to identify factors that can influence the survival of HIV-infected patients on HD. Methods: We performed a retrospective cohort study of 44 HIV-infected patients on HD. Results: A total of 17 patients (39%) died. Median survival on HD was 30.8 months and the survival rate at 1 and 5 years was 82.5 and 62.9%, respectively. Male (relative risk [RR] 3.1, p = 0.040) and blacks (RR 2.5, p = 0.037) had higher risk of death. The patients who died had a shorter duration of HIV infection (p = 0.028), had a higher viral load (p = 0.044), more opportunistic infections (p = 0.013), and a lower serum albumin (p = 0.009). Lower serum albumin, nonsexual HIV transmission, viral load, opportunistic infections, and usage of catheters were associated with lower survival. Conclusion: Several demographic, viral, and dialysis variables may help to predict survival of this population. The intervention in these factors could improve their prognosis.