Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome

• Published in: Curēus (Palo Alto, CA) Vol. 14; no. 4; p. e23724
• Main Authors: Paudel, Anish C, Altomare, John F, Shogbesan, Oluwaseun, Lee, Andrew, Desai, Parth, Noain, Jesus S, Khanal, Suravi
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 01.04.2022; Cureus
• Subjects: Anatomy; Blood platelets; Blood pressure; Blood transfusions; Case reports; Dehydrogenases; Enzymes; Gastroenterology; Hematoma; Hemoglobin; Hypoxia; Internal Medicine; Liver transplants; Maternal mortality; Patients; Preeclampsia; Sickle cell disease; Tomography; United States > US; hellp syndrome; elevated liver enzymes; preeclampsia; hepatic infarction; sickle cell trait
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.23724

Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and portal vein. The majority of the cases are caused following liver transplant or hepatobiliary surgery, hepatic artery occlusion, or shock. Hepatic infarction is a rare complication of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. HELLP is an obstetrical emergency requiring prompt delivery. The presence of elevated liver enzymes, mainly alanine aminotransferase and aspartate aminotransferase in pre-eclampsia, should warrant diagnosis and treatment in the line of HELLP syndrome. Our patient with underlying sickle cell trait presented with features of HELLP syndrome in her third trimester of pregnancy. She underwent cesarean delivery on the same day of the presentation. The liver enzymes continued to rise following delivery and peaked on postoperative day two. Contrast computed tomography scan showed multifocal hepatic infarctions. Pre-eclampsia by itself is a state of impaired oxygenation and can lead to hepatic hypoperfusion, and appeared to be a clear contributor to the hepatic infarction in this case. However, this case also raises the question of whether the underlying sickle cell trait might have potentiated the hepatic infarction. Although sickle cell disease is well known to cause hepatic infarctions, it is unknown whether the sickle cell trait affects the liver to a similar extent as sickle cell disease. In addition, there have been case reports of sickle cell trait causing splenic infarcts and renal papillary necrosis, but it remains unclear if it can be directly associated with hepatic infarction.