Mechanical characteristics of the globally ischaemic heart
Objective: The aim was to study the effects of global ischaemia on the mechanical properties of the myocardium. Methods: Myocardial ischaemia was achieved by incubating the hearts of 160 rats in normal saline at 37°C for periods of up to 24 h. To obtain different degrees of contracture, excess press...
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Published in | Cardiovascular research Vol. 27; no. 5; pp. 807 - 810 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.05.1993
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: The aim was to study the effects of global ischaemia on the mechanical properties of the myocardium. Methods: Myocardial ischaemia was achieved by incubating the hearts of 160 rats in normal saline at 37°C for periods of up to 24 h. To obtain different degrees of contracture, excess pressure (up to 150 mm Hg) was created in the left ventricles of subgroups of hearts. After incubation the hearts underwent mechanical loading. Results: Ischaemic contracture of cardiomyocytes led to increased rigidity and strength of the myocardium. A pressure of 50 mm Hg or higher blocked the increase in strength and rigidity of the ischaemic myocardium. Conclusions: It appears likely that in a functioning heart cardiomyocyte contracture in an ischaemic zone can only develop during the diastolic phase. A decrease in diastolic duration and/or an increase in diastolic pressure in the left ventricle may prevent increases in strength and rigidity of the ventricular wall after an infarct and promote the development of aneurysm and possible cardiac rupture. Cardiovascular Research 1993;27:807-810 |
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Bibliography: | ark:/67375/HXZ-F25TR575-V Correspondence to Dr Shlyachover. istex:3DEF0CC8F360BB218515FD4FAC32036F965F3980 ArticleID:27-5-807 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0008-6363 1755-3245 |
DOI: | 10.1093/cvr/27.5.807 |