A practical synthesis of tert-alkylamines via the Ritter reaction with chloroacetonitrile

Ritter reaction of tertiary alcohols with chloroacetonitrile and subsequent cleavage of chloroacetyl group in the resulting chloroacetamide with thiourea is an efficient procedure for synthesis of tert-alkylamines.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 12; pp. 1709 - 1712
Main Authors Jirgensons, A, Kauss, Kalvinsh, Gold, MR
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 2000
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Ritter reaction
amines
tertiary alcohols
amides
cleavage
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Summary:Ritter reaction of tertiary alcohols with chloroacetonitrile and subsequent cleavage of chloroacetyl group in the resulting chloroacetamide with thiourea is an efficient procedure for synthesis of tert-alkylamines.
ISSN:0039-7881
DOI:10.1055/s-2000-8208