Conformationally constrained DNA mimics: Synthesis of a novel cyclopropyl-amide linked dimer

Synthesis of a new conformationally constrained dimeric building-block containing a cyclopropyl-amide functionality is described. Potential application of this dimer for antisense oligonucleotides is discussed.

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Bibliographic Details
Published inSynlett no. 7; pp. 687 - 690
Main Authors Haly, B, Bharadwaj, R, Sanghvi, YS
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.07.1996
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
THYMIDINE
OLIGODEOXYNUCLEOTIDES
sugar-backbone conformation
ANALOGS
NUCLEOSIDES
OLIGONUCLEOTIDES
cyclopropyl nucleoside
amide backbone
LINKAGE
DERIVATIVES
BACKBONES
Michael reaction
antisense
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Summary:Synthesis of a new conformationally constrained dimeric building-block containing a cyclopropyl-amide functionality is described. Potential application of this dimer for antisense oligonucleotides is discussed.
ISSN:0936-5214
DOI:10.1055/s-1996-5570