Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units
The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic‐decipherable signals. We demonstrate a new method for obtaining read‐outs of molecular states that uses graphics processing units made from molecular circuits. Because they a...
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Published in | Angewandte Chemie Vol. 126; no. 35; pp. 9376 - 9379 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English German |
Published |
Weinheim
WILEY-VCH Verlag
25.08.2014
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic‐decipherable signals. We demonstrate a new method for obtaining read‐outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme‐based graphics processing units able to monitor nucleic acids and output alphanumerical read‐outs via a fluorescent display. Using this design we created a molecular 7‐segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics.
Molekularer Prozessor: Graphikprozessoren aus molekularen Schaltkreisen können Nukleinsäuren anzeigen und alphanumerische Werte über ein Fluoreszenzdisplay auslesen. Beschrieben werden eine molekulare siebensegmentige Anzeige, ein molekularer Rechner zur Addition und Multiplikation kleiner Zahlen und ein molekularer Automat zur Diagnose viraler Nukleinsäuresequenzen. Diese Module bieten Einblicke in die Konstruktion autonomer Biosensoren und elektronikfreier Rechner. |
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Bibliography: | ark:/67375/WNG-FV7QP457-N ArticleID:ANGE201402698 National Science Foundation - No. NSF-CCF 0829793; No. 0829881 Queensland Government Department of Science, Information Technology, Innovation and the Arts We thank Milan Stojanovic for critical discussions and reading of the manuscript. J.M. is also grateful for support from Donald Landry, Mark Porter, Noel Meyers, and Roland De Marco. This material is based upon work supported by the National Science Foundation NSF-CCF 0829793 and 0829881, and the Queensland Government Department of Science, Information Technology, Innovation and the Arts. istex:7354A32CAA39F39C0A8D01F14437C71C4C78C499 We thank Milan Stojanovic for critical discussions and reading of the manuscript. J.M. is also grateful for support from Donald Landry, Mark Porter, Noel Meyers, and Roland De Marco. This material is based upon work supported by the National Science Foundation NSF‐CCF 0829793 and 0829881, and the Queensland Government Department of Science, Information Technology, Innovation and the Arts. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.201402698 |