Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

• Published in: Angewandte Chemie Vol. 126; no. 35; pp. 9376 - 9379
• Main Authors: Poje, Julia E., Kastratovic, Tamara, Macdonald, Andrew R., Guillermo, Ana C., Troetti, Steven E., Jabado, Omar J., Fanning, M. Leigh, Stefanovic, Darko, Macdonald, Joanne
• Format: Journal Article
• Language: English; German
• Published: Weinheim WILEY-VCH Verlag 25.08.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Automation; Autonomous; Biosensoren; Chemistry; Devices; Displays; DNA-Computer; Ebola virus; Electronics; Graphics boards; Graphics processing units; Marburg virus; Molekulare Automaten; Molekulare Funktionseinheiten; Monitors; Nanostructure; Nanotechnologie; Sequences
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.201402698

The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic‐decipherable signals. We demonstrate a new method for obtaining read‐outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme‐based graphics processing units able to monitor nucleic acids and output alphanumerical read‐outs via a fluorescent display. Using this design we created a molecular 7‐segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics. Molekularer Prozessor: Graphikprozessoren aus molekularen Schaltkreisen können Nukleinsäuren anzeigen und alphanumerische Werte über ein Fluoreszenzdisplay auslesen. Beschrieben werden eine molekulare siebensegmentige Anzeige, ein molekularer Rechner zur Addition und Multiplikation kleiner Zahlen und ein molekularer Automat zur Diagnose viraler Nukleinsäuresequenzen. Diese Module bieten Einblicke in die Konstruktion autonomer Biosensoren und elektronikfreier Rechner.