Efficacy of gabapentinoids for acute herpes zoster in preventing postherpetic neuralgia: a systematic review of randomized controlled trials

• Published in: Dermatology online journal Vol. 28; no. 5
• Main Authors: Menaldi, Sri Linuwih, Halim, Paulus Anthony, Kurniawan, Kristian
• Format: Journal Article Book Review
• Language: English
• Published: United States University of California Digital Library - eScholarship 15.10.2022
• Subjects: Analgesics - adverse effects; Clinical trials; Gabapentin; Herpes Zoster - drug therapy; Humans; Neuralgia, Postherpetic - diagnosis; Neuralgia, Postherpetic - drug therapy; Neuralgia, Postherpetic - prevention & control; Randomized Controlled Trials as Topic; Systematic review
• ISSN: 1087-2108; 1087-2108
• DOI: 10.5070/D328559238

Gabapentinoids (e.g., gabapentin and pregabalin) have been established as a treatment for postherpetic neuralgia (PHN), but their effects on the prevention of PHN are unclear. This systematic review aimed to evaluate the efficacy of gabapentinoids for acute herpes zoster (HZ) in preventing PHN. PubMed, EMBASE, CENTRAL, and Web of Science were queried December 2020 to collect data on relevant randomized controlled trials (RCTs). A total of four RCTs (including 265 subjects) were retrieved. Overall, the incidence of PHN was lower, but not statistically significant in the gabapentinoid-treated group compared to the control group. Subjects treated with gabapentinoids were more likely to experience adverse events such as dizziness, somnolence, and gastrointestinal symptoms. This systematic review of RCTs showed that the addition of gabapentinoids during acute HZ are not significantly effective in preventing PHN. Nevertheless, the evidence on this subject remains limited. Physicians should carefully weigh the risks and benefits of prescribing gabapentinoids during the acute phase of HZ owing to its side effects.