Zn(OAc)2•2H2O-catalyzed efficient synthesis of 5-Substituted 1H-tetrazoles

In this communication, condensation from different aromatic, aliphatic and heteroaromatic aldehydes, hydroxyl amine, and sodium azide in toluene reflux was used to produce electronically and structurally distinct tetrazoles with a range of yields 5-94%. Zn(OAc)2•2H2O (10 mol%) was used as a catalyst...

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Bibliographic Details
Published inCurrent chemistry letters Vol. 12; no. 3; pp. 509 - 518
Main Authors Digambar, Kokane Balaji, Varala, Ravi, Patil, S. G.
Format Journal Article
LanguageEnglish
Published Growing Science 2023
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Summary:In this communication, condensation from different aromatic, aliphatic and heteroaromatic aldehydes, hydroxyl amine, and sodium azide in toluene reflux was used to produce electronically and structurally distinct tetrazoles with a range of yields 5-94%. Zn(OAc)2•2H2O (10 mol%) was used as a catalyst in the synthesis, which was eco-friendly, readily available, and affordable. The IR, NMR, and mass spectral studies were utilized in order to carry out a comprehensive characterization for all the 5-aryl tetrazole derivatives. This approach contributes to the current chemical synthesis of 5-substituted-1H-tetrazoles in an appealing and convenient manner thanks to its quick reaction times, good to exceptional yields, safe process, and straightforward workup.
ISSN:1927-7296
1927-730X
DOI:10.5267/j.ccl.2023.3.005