Preparation and Evaluation of Microcapsule Containing Volatile Oil of Herba Schizonepetae by Emulsion Solvent Diffusion Method

Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results...

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Published inTransactions of Tianjin University Vol. 20; no. 2; pp. 103 - 111
Main Author 张立国 欧阳霄雯 倪力军 史万忠
Format Journal Article
LanguageEnglish
Published Heidelberg Tianjin University 2014
Subjects
Engineering
GC-MS分析
Humanities and Social Sciences
Mechanical Engineering
multidisciplinary
Science
乳化溶剂
制备条件
十二烷基硫酸钠
微胶囊化
扩散法
挥发油
荆芥
microencapsulation
volatile oils
Herba Schizonepetae
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Summary:Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose（EC） to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils.
Bibliography:Zhang Liguo;Ouyang Xiaowen;Ni Lijun;Shi Wanzhong;School of Chemistry and Molecular Engineering,East China University of Science and Technology;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Herba Schizonepetae； volatile oils； microencapsulation
12-1248/T
Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose（EC） to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils.
ISSN:1006-4982
1995-8196
DOI:10.1007/s12209-014-2182-1