A Signal-Passing DNA-Strand-Exchange Mechanism for Active Self-Assembly of DNA Nanostructures

DNA nanostructured tiles play an active role in their own self‐assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the ti...

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Published inAngewandte Chemie Vol. 127; no. 20; pp. 6037 - 6040
Main Authors Padilla, Jennifer E., Sha, Ruojie, Kristiansen, Martin, Chen, Junghuei, Jonoska, Natasha, Seeman, Nadrian C.
Format Journal Article
LanguageEnglish
German
Published Weinheim WILEY-VCH Verlag 11.05.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Assembly
Autonomous
Binding
Binding sites
Cascading
Chemistry
Deoxyribonucleic acid
DNA
DNA-Kacheln
DNA-Strukturen
Nanostructure
Nanostructured materials
Nanotechnologie
Selbstorganisation
Self assembly
Strangverdrängung
Tiles
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Summary:DNA nanostructured tiles play an active role in their own self‐assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self‐assembly of tiles and enables local communication during the self‐assembly process. This localized signal‐passing mechanism provides a new element of control for autonomous self‐assembly of DNA nanostructures. Lange Leitung: Bei einer ausgelösten Selbstorganisation von DNA‐Nanokacheln sendet ein DNA‐Strangverdrängungsmechanismus ein Signal durch eine Kachel, was durch Aktivierung einer zweiten Bindestelle in 18 nm Entfernung zu einem Bindeereignis führt. Fünf verschiedene DNA‐Kacheln organisieren sich sequenziell in einer Dominokaskade.
Bibliography:NIGMS - No. GM-29554
ark:/67375/WNG-KMJ2DR08-T
ArticleID:ANGE201500252
This research has been supported by the National Science Foundation through grant CCF-1117210 to N.C.S., N.J., and J.E.P., by the NIH grant R01GM-109459-01 to N.J.; and the following grants to N.C.S.: from NIGMS grant GM-29554, from the NSF grants CMMI-1120890 and EFRI-1332411, from the ARO grant MURI W911NF-11-1-0024, from ONR grants N000141110729 and N000140911118, and from the Gordon and Betty Moore Foundation grant 3849. We would like to thank Yoel Ohayon for technical advice.
NSF - No. CMMI-1120890; No. EFRI-1332411
ARO - No. W911NF-11-1-0024
istex:11EF164E489E257142DE776820B901029DB6CFF0
Gordon and Betty Moore Foundation - No. 3849
National Science Foundation - No. CCF-1117210
NIH - No. R01GM-109459-01
ONR - No. N000141110729; No. N000140911118
This research has been supported by the National Science Foundation through grant CCF‐1117210 to N.C.S., N.J., and J.E.P., by the NIH grant R01GM‐109459‐01 to N.J.; and the following grants to N.C.S.: from NIGMS grant GM‐29554, from the NSF grants CMMI‐1120890 and EFRI‐1332411, from the ARO grant MURI W911NF‐11‐1‐0024, from ONR grants N000141110729 and N000140911118, and from the Gordon and Betty Moore Foundation grant 3849. We would like to thank Yoel Ohayon for technical advice.
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ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201500252