Prevention and management of glucocorticoid-induced side effects: A comprehensive review

Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple side effects can produce significant morbidity for patients. The objective of this review is to discuss these side effects while addressing 3 questions: 1) What dose and duration of glucocorticoid therapy...

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Published inJournal of the American Academy of Dermatology Vol. 76; no. 1; pp. 1 - 9
Main Authors Caplan, Avrom, MD, Fett, Nicole, MD, Rosenbach, Misha, MD, Werth, Victoria P., MD, Micheletti, Robert G., MD
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.01.2017
Subjects
Dermatology
glucocorticoids
medication monitoring
osteonecrosis
osteoporosis
pharmacology
side effects
steroids
pharmacology
side effects
osteonecrosis
steroids
glucocorticoids
osteoporosis
medication monitoring
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Summary:Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple side effects can produce significant morbidity for patients. The objective of this review is to discuss these side effects while addressing 3 questions: 1) What dose and duration of glucocorticoid therapy should prompt concern for individual side effects?; 2) How should clinicians counsel patients about these complications?; and 3) How can these problems be prevented or managed? To accomplish these objectives, we have created a series of tables and algorithms based on a review of relevant data to guide counseling, prophylaxis, and management of 11 glucocorticoid side effects. The first article in this 4-part continuing medical education series begins with a review of glucocorticoid pharmacology followed by a discussion of bone health (ie, osteoporosis and osteonecrosis).
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2016.01.062