Surgical resection of primary intracardiac sarcomas and outcomes A review of case reports over 20 years

• Published in: Indian journal of thoracic and cardiovascular surgery Vol. 40; no. 2; pp. 213 - 218
• Main Authors: Mayooran, Nithiananthan, Sherif, A., Koulouroudias, M., Gnanalingham, S., Ahmed Saleh, W. U., Tan, S., Boulemden, A., Szafranek, A.
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.03.2024
• Subjects: Cardiac Surgery; Medicine; Medicine & Public Health; Mini Review Article; Surgery; Thoracic Surgery; Vascular Surgery; Surgical resection; Prognosis; Cardiac sarcoma; Follow-up
• ISSN: 0970-9134; 0973-7723
• DOI: 10.1007/s12055-023-01618-0

Objective A quarter of all cardiac tumors are malignant, and most (~ 95%) are sarcomas. It is the most aggressive malignant cardiac tumor carrying the worst prognosis. Tumor involvement with the vital intracardiac structures makes it difficult for complete surgical resection. We aimed to study the role of complete surgical resection and its importance in long-term outcomes. Methods We analyzed published literature from 2002 to 2022 using PubMed. Cases reported adult, intracardiac sarcomas, and received surgical resections were included. We reviewed 132 published case reports, including and analyzed the following variables: demographics, clinical presentations, diagnostic imaging modality, the extent of surgical resection, pathological diagnosis, tumor location, postoperative chemo-radiation therapy, and follow-up (including re-operation, local and distant recurrence). Results A total of 135 patients are included from 132 articles. The mean age was 46.69 (18–86) and 76 patients were females. The main complaints were dyspnea (70%) and chest pain (32%). Performed investigations were transthoracic echocardiography (TTE) in 114/135 (84%), computer tomography (CT) scan 89/135 (66%), trans-esophageal echocardiography (TOE) 22%, and cardiac magnetic resonance imaging (MRI) 29%. The most common location was the atrium (left 46%, right 30%). Complete surgical resection was performed in 91 cases (67%), and frozen section was performed in 62 patients (43 positives). Incomplete resections were in 42 cases. Patients who underwent complete surgical resection had mean survival of 14.58 months and median of 10.5 months, compared to incomplete resection patients with 9.12 months and 6.5 months respectively. Conclusion Our review shows complete surgical resection results in better short- and long-term outcomes in intracardiac sarcoma patients. Furthermore, combining chemo-radiotherapy has additional benefits towards long-term survival.