Induction of bladder lesion by terephthalic acid and its mechanism

To provide more information for rational evaluation of potential risks of terephthalic acid (TPA), we studied the effects of TPA on rats' bladders in 90 days after TPA exposure. Sprague Dawley rats were subdivided into five groups, ingesting 0%, 0.04%, 0.2%, 1%, and 5% TPA respectively for a su...

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Published inBiomedical and environmental sciences Vol. 18; no. 4; p. 211
Main Authors Dai, Gui-Dong, Cui, Lun-Biao, Song, Ling, Zhao, Ren-Zhen, Cheng, Jian-Feng, Liu, Mei-Xia, Zhou, Jian-Wei, Xiao, Hang, Wang, Xin-Ru
Format Journal Article
LanguageEnglish
Published China 01.08.2005
Subjects
Alpha-Globulins - urine
Animals
Biomarkers - urine
Female
Hyperplasia - chemically induced
Male
Phthalic Acids - toxicity
Rats
Rats, Sprague-Dawley
Urinary Bladder - drug effects
Urinary Bladder - pathology
Urinary Bladder Calculi - chemically induced
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Summary:To provide more information for rational evaluation of potential risks of terephthalic acid (TPA), we studied the effects of TPA on rats' bladders in 90 days after TPA exposure. Sprague Dawley rats were subdivided into five groups, ingesting 0%, 0.04%, 0.2%, 1%, and 5% TPA respectively for a sub-chronic feeding study lasting for 90 days. Urine, serum and samples of brain, liver, lung, kidney, bladder, etc. were collected and analyzed. TPA ingesting decreased the value of urinary pH, and increased the contents of Ca2+, Zn2+, Mg2+, Na+, K+ in urine. The volume of 24 h urine was significantly increased in male rats in the 1% and 5% TPA groups. Urinary white sediment was found in both sexes, and its formation in male rats seemed more susceptible than that in female rats. Alpha 2u-globulin (AUG) in serum and urine of male rats was markedly increased in a dose-dependent manner. Fifteen cases of hyperplasia (simple or atypical) were determined in the 5% TPA ingesting group, 14/52 in male rats and 1/23 in female rats. Among them 3 male rats had no stone or calculus. Those with either bladder stones or hyperplasia were accompanied with urinary white sediments. White sediment accompanied with elevated urine AUG is the basis of TPA induced urolith formation, and is also associated with TPA induced bladder epithelial cell proliferation. It can act as an early biomarker for the potential toxic effect of TPA.
ISSN:0895-3988