64Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging

• Published in: Chinese chemical letters Vol. 33; no. 7; pp. 3349 - 3360
• Main Authors: Chen, Xueqian, Niu, Wenchao, Du, Zhongying, Zhang, Yong, Su, Dongdong, Gao, Xueyun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2022; Department of Chemistry and Biology,Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China
• Subjects: 64Cu; Chelating agent-free; Imaging guided therapy; Positron emission tomography; Radiolabeling strategies; 64Cu; Imaging guided therapy; Chelating agent-free; Positron emission tomography; Radiolabeling strategies
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2022.02.070

The prevalence of positron emission tomography (PET) imaging has advanced biomedical applications for its ultrahigh sensitivity, deep tissue penetration and quantitative visualization of diseases in vivo. 64Cu with ideal half-life and decay characteristics has been designed as radioactive probes for disease diagnosis. The currently reported 64Cu-labeled nanomaterials have the advantages of long circulation time in serum, good biocompatibility and mature preparation methods, and have been used in vivo PET imaging, biodistribution and pharmacokinetic monitoring, and imaging guided therapy. At the same time, suitable carrier characteristics and radiolabeling strategies are particularly important in the 64Cu PET imaging process. In this review, we summarize different imaging probe designs and 64Cu radiolabeling strategies, as well as their eventual applications in biomedicine. The potential challenges and prospects of 64Cu labeled nanomaterials are also described, which provides broad prospects for radiolabeling strategies and further applications. We introduced in detail the design strategies and synthetic methodologies of various 64Cu radiolabeled nanoprobes, mainly the latest developments and applications of chelating agent-free 64Cu radiolabeled nanomaterials, and predicted their development trends. [Display omitted]