A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+in vivo

• Published in: Chinese chemical letters Vol. 31; no. 11; pp. 2941 - 2944
• Main Authors: Huang, Lina, Chen, Yu, Zhao, Yuqiang, Wang, Yumin, Xiong, Junwei, Zhang, Junfeng, Wu, Xianghua, Zhou, Ying
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2020; College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China%College of Chemical Science and Technology,Yunnan University,Kunming 650091,China
• Subjects: Fe2; Fluorescent probe; Naphthalimide; Near-infrared; Ratiometric; Fe2; Naphthalimide; Fluorescent probe; Ratiometric; Near-infrared
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2020.06.006

We synthesized a novel near-infrared intramolecular charge transfer (ICT) based ratiometric fluorescent probe 1, using naphthalimide and indole moieties as building blocks, to detect Fe2+. Probe 1 can successfully perform real-time monitoring of Fe2+ in HeLa cells and C. elegans. [Display omitted] Iron is one of the essential trace elements in the human body. It plays an important role in human biology and pathology. Deregulation of iron levels in cells is associated with disease development. In this work, we synthesized a novel near-infrared intramolecular charge transfer (ICT) based ratiometric fluorescent probe to detect Fe2+, by using naphthalimide and indole moieties as building blocks. Our work showed that the radiometric probe has excellent selectivity, sensitivity and rapid response. Moreover, we could successfully perform real-time monitoring of Fe2+ in HeLa cells and C. elegans.