On load dependence of detachment rate of kinesin motor
Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the mo...
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| Published in | Chinese physics B Vol. 34; no. 1; pp. 18702 - 504 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Chinese Physical Society and IOP Publishing Ltd
01.01.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1056 2058-3834 |
| DOI | 10.1088/1674-1056/ad8ec7 |
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| Abstract | Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data, we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor. |
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| AbstractList | Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells.The load dependence of the detachment rate is an important factor of the kinesin motor,the determination of which is critically related to the chemomechanical coupling mechanism of the motor.Here,we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor.By comparing the theoretical and numerical results with the available experimental data,we show that only one model can explain well the available experimental data,indicating that only this model can be applicable to the kinesin motor. |
| Author | Wang, Yao Shi, Xiao-Xuan Liu, Yu-Ru Xie, Ping |
| Author_xml | – sequence: 1 givenname: Xiao-Xuan surname: Shi fullname: Shi, Xiao-Xuan organization: School of Pharmaceutical Engineering, Chongqing Chemical Industry Vocational College , Chongqing 401220, China – sequence: 2 givenname: Yao surname: Wang fullname: Wang, Yao organization: Institute of Physics, Chinese Academy of Sciences Laboratory of Soft Matter Physics, Beijing 100190, China – sequence: 3 givenname: Yu-Ru surname: Liu fullname: Liu, Yu-Ru organization: Institute of Physics, Chinese Academy of Sciences Laboratory of Soft Matter Physics, Beijing 100190, China – sequence: 4 givenname: Ping surname: Xie fullname: Xie, Ping organization: Institute of Physics, Chinese Academy of Sciences Laboratory of Soft Matter Physics, Beijing 100190, China |
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| Keywords | generated force optical trap-ping detachment rate chemomechanical coupling mechanism kinesin |
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| Title | On load dependence of detachment rate of kinesin motor |
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