On load dependence of detachment rate of kinesin motor

Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the mo...

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Published inChinese physics B Vol. 34; no. 1; pp. 18702 - 504
Main Authors Shi, Xiao-Xuan, Wang, Yao, Liu, Yu-Ru, Xie, Ping
Format Journal Article
LanguageEnglish
Published Chinese Physical Society and IOP Publishing Ltd 01.01.2025
Subjects
chemomechanical coupling mechanism
detachment rate
generated force
kinesin
optical trapping
generated force
optical trap-ping
detachment rate
chemomechanical coupling mechanism
kinesin
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Summary:Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data, we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.
ISSN:1674-1056
2058-3834
DOI:10.1088/1674-1056/ad8ec7