Neuroimmunology in neurological and psychiatric disorders

• Published in: Clinical & experimental neuroimmunology Vol. 12; no. 2; pp. 92 - 100
• Main Author: Takeuchi, Hideyuki
• Format: Journal Article
• Language: English
• Published: Ube Wiley Subscription Services, Inc 01.05.2021
• Subjects: Autism; Central nervous system; Dementia disorders; Homeostasis; Immune system; Inflammation; Mental disorders; Neurodegenerative diseases; Neuroimmunology; neuroinflammation; Neurological diseases; neurological disorders; Neuronal-glial interactions; psychiatric disorders; Schizophrenia; Trauma
• ISSN: 1759-1961; 1759-1961
• DOI: 10.1111/cen3.12639

The central nervous system (CNS) has long been considered as an immunological privileged site where the surveillance of the immune system does not reach out. However, it is now recognized that this CNS homeostasis is collapsed by neuroinflammation such as influx of proinflammatory factors and cells, neuronal dysfunction, and glial activation. Currently, CNS neuroinflammation is considered as a main pathomechanism to mediate disease progression in not only neurotrauma and neuroinflammatory disorders but also neurodegenerative diseases including dementia. Moreover, growing evidence indicates that chronic CNS neuroinflammation is also involved in the pathogenesis of psychiatric disorders such as autism spectrum disorders, depression, and schizophrenia. This paper reviews the current proposed pathomechanisms and therapeutic strategies of neurological and psychiatric disorders from a point of view of chronic neuroinflammation. This paper reviews the current proposed pathomechanisms and therapeutic strategies of neurological and psychiatric disorders from a point of view of chronic neuroinflammation.