From pathogenesis to treatment: the impact of bacteria on cancer

The intricate relationship between cancer and bacteria has garnered increasing attention in recent years. While traditional cancer research has primarily focused on tumor cells and genetic mutations, emerging evidence highlights the significant role of microbial communities within the tumor microenv...

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Bibliographic Details
Published inFrontiers in microbiology Vol. 15; p. 1462749
Main Authors Lu, Jiatong, Tong, Qiang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.09.2024
Subjects
bacteria
cancer
Microbiology
therapeutic strategies
tumor prediction
tumorigenesis
cancer
tumorigenesis
bacteria
tumor prediction
therapeutic strategies
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Summary:The intricate relationship between cancer and bacteria has garnered increasing attention in recent years. While traditional cancer research has primarily focused on tumor cells and genetic mutations, emerging evidence highlights the significant role of microbial communities within the tumor microenvironment in cancer development and progression. This review aims to provide a comprehensive overview of the current understanding of the complex interplay between cancer and bacteria. We explore the diverse ways in which bacteria influence tumorigenesis and tumor behavior, discussing direct interactions between bacteria and tumor cells, their impact on tumor immunity, and the potential modulation of the tumor microenvironment. Additionally, we delve into the mechanisms through which bacterial metabolites and extracellular products May affect cancer pathways. By conducting a thorough analysis of the existing literature, we underscore the multifaceted and intricate relationship between bacteria and cancer. Understanding this complex interplay could pave the way for novel therapeutic approaches and preventive strategies in cancer treatment.
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Songhe Guo, Sun Yat-sen University Cancer Center (SYSUCC), China
Reviewed by: Le Liu, Southern Medical University, China
Edited by: Pragya Tiwari, Yeungnam University, Republic of Korea
Zhengrui Li, Shanghai Jiao Tong University, China
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1462749