Antimutagenic and anticancer activity of Al Madinah Alhasawy mint (Mentha longifolia) leaves extract

Mentha is one of the genera of Lamiaceae family. The aim of the present study was to evaluate the antimutagenic and anticancer activity of the water and methanolic extract of Alhasawy mint (Mentha longifolia), that grown in Madina Province, western region, Saudi Arabia using three different bioassay...

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Bibliographic Details
Published inPakistan journal of biological sciences Vol. 17; no. 12; pp. 1231 - 1236
Main Authors Al-Ali, Khalil, Abdelrazik, Mohamad, Alghaithy, Abdulaziz, Diab, Atef, El-Beshbishy, Hesham, Baghdadi, Hussam
Format Journal Article
LanguageEnglish
Published Pakistan 01.12.2014
Subjects
Animals
Antimutagenic Agents - chemistry
Antimutagenic Agents - isolation & purification
Antimutagenic Agents - pharmacology
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Artemia - drug effects
Artemia - embryology
Biological Assay
Cell Survival - drug effects
Cercopithecus aethiops
Dose-Response Relationship, Drug
Hep G2 Cells
Humans
Larva - drug effects
Mentha - chemistry
Methanol - chemistry
Mutagenicity Tests
Mutation - drug effects
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Leaves
Plants, Medicinal
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
Solvents - chemistry
Vero Cells
Water - chemistry
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Summary:Mentha is one of the genera of Lamiaceae family. The aim of the present study was to evaluate the antimutagenic and anticancer activity of the water and methanolic extract of Alhasawy mint (Mentha longifolia), that grown in Madina Province, western region, Saudi Arabia using three different bioassays namely; Brine shrimp bioassay, Ames mutagenicity bioassay using 3 Hist-Salmonella typhimurium strains of different mutations (TA98, TA97 and TA100) and 2 reference mutagenic drugs nitrosopiperidine (NP) and 2-amino-3-methylimidazo-quinolidine (IQ) and Mammalian cell lines bioassays using 2 different cell lines HepG2 and Vero cell lines. The plant extract showed an efficient antimutagenic activity against the studied bioassays in a directly proportional effect with concentration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1028-8880
DOI:10.3923/pjbs.2014.1231.1236