ALPHA-CYANOTHIOACETAMIDE AND ITS DERIVATIVES IN HETEROCYCLIC SYNTHESIS - PREPARATION OF SEVERAL NEW 4-OXOQUINAZOLINE DERIVATIVES

The reaction of alpha-cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4-dihydro-4-oxoquinazolin-2-yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a-d) which could be prepared also via the reaction of 2-t...

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Published inJournal für praktische Chemie (Leipzig, Germany : 1954) Vol. 332; no. 5; pp. 610 - 618
Main Authors AZIZ, MAA, DABOUN, HA, GAWAD, SMA
Format Journal Article
LanguageEnglish
Published HEIDELBERG JOHANN AMBROSIUS BARTH VERLAG 01.01.1990
Subjects
Chemistry
Chemistry, Applied
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:The reaction of alpha-cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4-dihydro-4-oxoquinazolin-2-yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a-d) which could be prepared also via the reaction of 2-thiocarbamoylcinnamonitriles (5a-d) or their methylthio derivatives (6a-d) with anthranilic acid. 3 reacted with cinnamonitrile derivatives (7a-h) and (12a-d) to yield pyrido-[1,2-a]-quinazoline derivatives (10a-h) and (15a-d) which could also be prepared by the reaction of (4a-d) with malononitrile (11a), benzoyl acetonitrile (11b) and ethylcyanoacetate (16), respectively.
ISSN:0021-8383
DOI:10.1002/prac.19903320505