Diffuse Myocardial Uptake of 99mTc-HDP in Multiple Myeloma

• Published in: Nuclear medicine and molecular imaging Vol. 47; no. 3; pp. 208 - 211
• Main Authors: Demirel, Koray, Sadic, Murat, Korkmaz, Meliha, Comak, Aylin, Atilgan, Hasan Ikbal, Koca, Gökhan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2013; 대한핵의학회
• Subjects: Cardiology; Case Report; Imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Orthopedics; Radiology; 방사선과학; Technetium-99m hydroxymethylene diphosphonate; Tc-HDP; Myocardial uptake; Technetium-99m bone agents; Multiple myeloma
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-013-0209-5

Soft tissue uptake is a rare finding in bone scintigraphy, with an incidence of 2%. Although the mechanism has not yet been fully clarified, several causes have been reported for this unusual uptake pattern. This paper presents a case of diffuse myocardial accumulation of technetium-99m hydroxymethylene diphosphonate ( 99m Tc-HDP) without either solid/visceral organ or soft tissue with multiple myeloma (MM) in skeletal scintigraphy. A 93-year-old man with hypertension and chronic heart failure for 14 years underwent bone scanning due to a 2-month history of back pain within a 1-year period of MM. Three hours later, 99m Tc-HDP late static images showed diffuse myocardial radiotracer accumulation and there were no other sites of abnormal soft tissue or visceral uptake. Myocardial accumulation had disappeared on 24-h delayed static images. This accumulation was thought to be related with AL-type amyloidosis associated with MM.