Glioma stem cells and their microenvironment: A narrative review on docking and transformation

Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor microenvironment (TME) transformation: (1) Because GSCs also have heterogeneity, they are a state, not an entity. (2) The importance of the bord...

Full description

Saved in:
Bibliographic Details
Published inGlioma Vol. 5; no. 1; pp. 12 - 19
Main Authors Zhu, Wenyu, Chen, Hua, Yan, Ke, Wu, Jie, Zhao, Yaodong, Huang, Qiang
Format Journal Article
LanguageEnglish
Published Wolters Kluwer - Medknow Publications 01.01.2022
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Cancer
Chemotherapy
cytomegalovirus infects glioma
embryonic stem cell
epithelial-stromal transformation of glioma
glioblastoma
glioma
glioma microenvironment
glioma stem cell niche
glioma stem cells
Gliomas
mesenchymal stem cells
remodeling of glioma microenvironment
Stem cells
epithelial-stromal transformation of glioma
glioblastoma
Cytomegalovirus infects glioma
embryonic stem cell
glioma stem cell niche
glioma microenvironment
mesenchymal stem cells
glioma
glioma stem cells
remodeling of glioma microenvironment
Online AccessGet full text

Cover

Abstract Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor microenvironment (TME) transformation: (1) Because GSCs also have heterogeneity, they are a state, not an entity. (2) The importance of the border niche among many tumor niches is emphasized because it is a shelter for tumor resistance to radiotherapy and chemotherapy. (3) The plasticity of GSCs and TME cells allows TME cells to become GSC-initiating cells. (4) Future development will entail a close interaction between high-throughput molecular biology and artificial intelligence. In this review, we summarize recent advances in GSCs and their microenvironment from the following three aspects: the constantly updated of concept of stem cells, the concept of TME and niche, and the plasticity of GSCs and TME cells.
AbstractList Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor microenvironment (TME) transformation: (1) Because GSCs also have heterogeneity, they are a state, not an entity. (2) The importance of the border niche among many tumor niches is emphasized because it is a shelter for tumor resistance to radiotherapy and chemotherapy. (3) The plasticity of GSCs and TME cells allows TME cells to become GSC-initiating cells. (4) Future development will entail a close interaction between high-throughput molecular biology and artificial intelligence. In this review, we summarize recent advances in GSCs and their microenvironment from the following three aspects: the constantly updated of concept of stem cells, the concept of TME and niche, and the plasticity of GSCs and TME cells.
Audience Academic
Author Chen, Hua
Wu, Jie
Zhao, Yaodong
Huang, Qiang
Zhu, Wenyu
Yan, Ke
Author_xml – sequence: 1
  givenname: Wenyu
  surname: Zhu
  fullname: Zhu, Wenyu
  organization: Department of Neurosurgery, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu Province
– sequence: 2
  givenname: Hua
  surname: Chen
  fullname: Chen, Hua
  organization: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province
– sequence: 3
  givenname: Ke
  surname: Yan
  fullname: Yan, Ke
  organization: Department of Neurosurgery, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu Province
– sequence: 4
  givenname: Jie
  surname: Wu
  fullname: Wu, Jie
  organization: Department of Neurosurgery, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu Province
– sequence: 5
  givenname: Yaodong
  surname: Zhao
  fullname: Zhao, Yaodong
  organization: Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
– sequence: 6
  givenname: Qiang
  surname: Huang
  fullname: Huang, Qiang
  organization: Department of Neurosurgery and Brain Tumor Research Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
BookMark eNp9kU9r3DAQxUVJIWmaL5CToOfd6o8t2b0toU0DgV6SawZZGm3VtaUiubv020dZp6GFEgQaMbz30MzvHTmJKSIhl5ytG87kx-0Y0mTWS4EWhHhDzkTb9SvFBT95eXN5Si5KCQNrlBKat_qMPFwfXbTMOFGL41ioiY7O3zFkOgWbE8Z9yClOGOdPdEOjydnMYY804z7ggaZIXbK7ELeLM5tYfMpTFaX4nrz1Zix48VzPyf2Xz3dXX1e3365vrja3KytUs19x3Rk3DJoNPXKnlW1aJ6Wvt-GdHZSocwjGGOLQNSgYd4OWqGWneuOaXshzcrPkumR-wM8cJpN_QzIBjo2Ut2DyHOyI0Dku6i6Mdq5vpFams34Q2HYKnfe9rlkflqytqfIQfaoz2SkUCxvV91JrqZuqWv9HVY_DurYKyIfa_8cgFkPdaSkZ_cs3OYMnjvAM8C-O1QSL6ZDGGXPZjb8OmGFCt4vp8IoTuIAFLTyhhSNaqIDgiBb-oJWP8gu6kQ
Cites_doi 10.1182/blood-2002-08-2509
10.1007/s10014-017-0291-y
10.1016/j.ebiom.2019.07.039
10.1038/488013a
10.1523/JNEUROSCI.2001-12.2013
10.1038/s41374-021-00695-2
10.1111/cpr.12865
10.1016/j.neuroscience.2013.10.050
10.1186/s12859-018-2157-7
10.3389/fimmu.2018.01004
10.1007/s10072-018-3408-0
10.2353/ajpath.2009.081034
10.1073/pnas.1414389111
10.1016/j.stem.2008.07.027
10.1038/nature06965
10.1016/j.bbcan.2020.188458
10.1371/journal.pbio.1000149
10.1093/neuonc/nox126
10.1016/j.ccell.2020.04.001
10.1038/nature24014
10.1016/j.conb.2017.09.014
10.1007/s10014-019-00341-2
10.1126/science.aai8478
10.1189/jlb.3RI1116-494R
10.1002/prca.201700056
10.1007/s11060-018-03010-0
10.1007/s00259-019-04414-4
10.1007/s11912-018-0673-2
10.1038/sj.onc.1207946
10.1186/s12859-018-2300-5
10.1002/jbio.201700011
10.1016/j.canlet.2015.05.026
10.1038/nmeth.2930
10.1158/0008-5472.CAN-16-2310
10.1016/j.bbamcr.2020.118782
10.1038/gim.2017.157
10.1016/j.devcel.2005.10.017
10.1038/nature09781
10.3390/cells8111398
10.3892/or.2015.4281
10.4252/wjsc.v13.i7.877
10.1038/nature12752
10.1073/pnas.1717139115
10.1002/jnr.22065
10.1371/journal.pcbi.1000217
10.1155/2019/5189232
10.1016/j.stem.2008.03.021
10.1126/scitranslmed.3009095
10.1038/ncb3629
10.1158/0008-5472.CAN-13-0813
10.1371/journal.pone.0032453
10.1155/2017/9634172
10.1111/nan.12772
10.1158/0008-5472.CAN-18-0650
10.1016/j.cell.2011.06.014
10.1016/j.cell.2015.04.012
10.1016/j.ebiom.2018.02.024
10.1016/j.jprot.2019.103578
10.1093/jamia/ocx032
10.1093/neuonc/noab175
10.1002/jbio.201900136
10.1007/s12035-020-02240-6
10.1016/j.mcn.2005.10.006
10.1002/glia.23520
10.5732/cjc.011.10336
10.2217/epi.13.35
10.1016/j.stem.2010.11.015
10.1038/s41593-019-0540-y
10.1111/cas.14545
10.1038/nature06403
10.3389/fimmu.2018.02924
10.1523/JNEUROSCI.1619-13.2014
10.1186/s13073-018-0564-z
10.1038/s41467-017-02719-2
10.1093/brain/awz044
10.1038/nature03128
10.1039/C8LC01130C
10.1007/s10456-017-9565-6
10.1016/j.neuron.2013.01.006
10.1016/j.cell.2019.06.024
10.1016/j.tcb.2018.09.005
10.1002/jbio.201900006
10.3892/mmr.2014.3032
10.1523/JNEUROSCI.22-19-08553.2002
10.3390/ijms18112342
10.1172/jci.insight.122264
10.1186/1471-2407-8-304
10.1038/s41467-017-02465-5
10.2176/nmc.ra2013-0207
10.3389/fncel.2021.709917
10.1126/science.1252304
10.1039/C9MO00068B
10.1055/s-0039-1677945
10.4103/1673-5374.219055
10.1039/c1mb05398a
10.3390/cancers11010005
10.1017/S1740925X09990354
10.1002/jnr.22482
10.1007/s12035-018-0880-8
10.1158/0008-5472.CAN-05-1842
10.1038/sj.cr.7310104
10.1016/j.devcel.2015.01.016
10.1016/j.stem.2009.08.001
10.7150/jca.54402
10.1001/jamaoncol.2016.2631
10.1016/j.canlet.2013.06.020
10.21037/tcr.2016.12.05
10.1186/s40478-019-0819-y
10.1038/nrg2046
10.1038/nn.3371
ContentType Journal Article
Copyright COPYRIGHT 2022 Medknow Publications and Media Pvt. Ltd.
Copyright_xml – notice: COPYRIGHT 2022 Medknow Publications and Media Pvt. Ltd.
DBID AAYXX
CITATION
DOA
DOI 10.4103/glioma.glioma_5_22
DatabaseName CrossRef
Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2589-6121
EndPage 19
ExternalDocumentID oai_doaj_org_article_8d12611a7dd94376a8cfb2e586edff97
A699377374
10_4103_glioma_glioma_5_22
10.4103/glioma.glioma_5_22_12_Glioma stem cells and their microenv
GroupedDBID ADBBV
ALMA_UNASSIGNED_HOLDINGS
BCNDV
GROUPED_DOAJ
IAO
IHR
INH
RMW
W3E
AAYXX
CITATION
OK1
ABDBF
H13
ITC
OVD
TEORI
ID FETCH-LOGICAL-c264v-178adbb70b9e1d76c45d33f45da18cb621212000eeb84e201db73e73869ad4923
IEDL.DBID DOA
ISSN 2589-6113
IngestDate Tue Oct 22 15:16:16 EDT 2024
Thu Feb 22 23:31:16 EST 2024
Wed Oct 25 09:39:10 EDT 2023
Wed Sep 11 13:54:11 EDT 2024
Wed Apr 06 12:38:10 EDT 2022
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords epithelial-stromal transformation of glioma
glioblastoma
Cytomegalovirus infects glioma
embryonic stem cell
glioma stem cell niche
glioma microenvironment
mesenchymal stem cells
glioma
glioma stem cells
remodeling of glioma microenvironment
Language English
License http://creativecommons.org/licenses/by-nc-sa/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c264v-178adbb70b9e1d76c45d33f45da18cb621212000eeb84e201db73e73869ad4923
OpenAccessLink https://doaj.org/article/8d12611a7dd94376a8cfb2e586edff97
PageCount 8
ParticipantIDs doaj_primary_oai_doaj_org_article_8d12611a7dd94376a8cfb2e586edff97
gale_infotracmisc_A699377374
gale_infotracacademiconefile_A699377374
crossref_primary_10_4103_glioma_glioma_5_22
wolterskluwer_medknow_10_4103_glioma_glioma_5_22_12_Glioma_stem_cells_and_their_microenv
PublicationCentury 2000
PublicationDate 20220101
2022-01-00
2022-01-01
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – month: 1
  year: 2022
  text: 20220101
  day: 01
PublicationDecade 2020
PublicationTitle Glioma
PublicationYear 2022
Publisher Wolters Kluwer - Medknow Publications
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Publisher_xml – name: Wolters Kluwer - Medknow Publications
– name: Medknow Publications and Media Pvt. Ltd
– name: Wolters Kluwer Medknow Publications
References Elshamy (R70-3-20240909) 2013; 341
Huang (R3-3-20240909) 2008; 8
Suvà (R32-3-20240909) 2020; 37
Hide (R40-3-20240909) 2013; 53
Mobadersany (R105-3-20240909) 2018; 115
Lundgaard (R56-3-20240909) 2014; 276
Barcia (R55-3-20240909) 2009; 175
Perestrelo (R25-3-20240909) 2018; 28
Zhang (R34-3-20240909) 2021; 13
Hill (R75-3-20240909) 2013; 33
Johnson (R94-3-20240909) 2018; 20
Trott (R20-3-20240909) 2012; 8
Young (R72-3-20240909) 2013; 77
Castiglioni (R102-3-20240909) 2019; 46
Chen (R77-3-20240909) 2015; 365
Smaïl-Tabbone (R108-3-20240909) 2019; 28
Zhu (R85-3-20240909) 2020; 13
Venkatesh (R61-3-20240909) 2015; 161
Behnan (R88-3-20240909) 2019; 142
Schiffer (R35-3-20240909) 2018; 11
Reid (R29-3-20240909) 2017; 19
Guan (R52-3-20240909) 2018; 55
Brandao (R53-3-20240909) 2019; 67
Cai (R87-3-20240909) 2019; 19
Venkatesh (R62-3-20240909) 2017; 549
Ma (R86-3-20240909) 2018; 9
Sørensen (R31-3-20240909) 2022; 48
Liu (R44-3-20240909) 2011; 146
Chen (R51-3-20240909) 2018; 9
Buser (R89-3-20240909) 2019; 46
Katz (R54-3-20240909) 2012; 7
Huang (R9-3-20240909) 2010; 32
Lee (R111-3-20240909) 2008; 4
Efroni (R12-3-20240909) 2008; 2
Lin (R74-3-20240909) 2009; 87
Wang (R23-3-20240909) 2022; 13
Belachew (R73-3-20240909) 2002; 22
Zhu (R26-3-20240909) 2010; 7
Zhao (R5-3-20240909) 2017; 12
Lei (R80-3-20240909) 2016; 5
Doostparast Torshizi (R107-3-20240909) 2018; 25
Bardehle (R58-3-20240909) 2013; 16
Macarthur (R64-3-20240909) 2014; 74
Li (R91-3-20240909) 2020; 211
Wan (R4-3-20240909) 2012; 31
Singh (R7-3-20240909) 2004; 23
Sharma (R30-3-20240909) 2022; 24
Innes (R83-3-20240909) 2022; 102
Fang (R103-3-20240909) 2019; 12
Li (R100-3-20240909) 2017; 10
Butovsky (R47-3-20240909) 2006; 31
Mitew (R60-3-20240909) 2018; 9
Akter (R113-3-20240909) 2021; 1875
Dasgupta (R66-3-20240909) 2005; 65
Baker (R10-3-20240909) 2012; 488
Saurty-Seerunghen (R95-3-20240909) 2019; 7
Lan (R81-3-20240909) 2020; 111
Grün (R17-3-20240909) 2014; 11
Yoshida (R27-3-20240909) 2009; 5
Sengupta (R106-3-20240909) 2018; 10
Aerts (R97-3-20240909) 2016; 2
Krempel (R110-3-20240909) 2018; 19
Singh (R1-3-20240909) 2004; 432
Kaller (R43-3-20240909) 2017; 47
Cheng (R68-3-20240909) 2020; 53
Wang (R90-3-20240909) 2020; 16
Tirosh (R93-3-20240909) 2018; 20
Wang (R78-3-20240909) 2015; 11
Dai (R79-3-20240909) 2015; 34
Hide (R41-3-20240909) 2019; 36
Chang (R16-3-20240909) 2008; 453
Psachoulia (R71-3-20240909) 2009; 5
Schiffer (R37-3-20240909) 2018; 39
Terskikh (R15-3-20240909) 2003; 102
Chambers (R18-3-20240909) 2007; 450
Paldi (R24-3-20240909) 2013; 5
Visvader (R76-3-20240909) 2011; 469
Gibson (R59-3-20240909) 2014; 344
Liu (R67-3-20240909) 2018; 78
Ho (R38-3-20240909) 2017; 2017
Shigemoto-Mogami (R48-3-20240909) 2014; 34
Meshorer (R13-3-20240909) 2006; 10
Moscatelli (R109-3-20240909) 2018; 19
Zhang (R2-3-20240909) 2006; 16
Müller (R63-3-20240909) 2014; 6
Fang (R98-3-20240909) 2019; 12
Kanwore (R22-3-20240909) 2021; 58
Bagley (R96-3-20240909) 2019; 141
Diksin (R36-3-20240909) 2017; 18
Hayashi (R19-3-20240909) 2008; 3
Chen (R50-3-20240909) 2017; 77
Majc (R84-3-20240909) 2020; 1867
Gut (R28-3-20240909) 2013; 502
Venteicher (R92-3-20240909) 2017; 355
Jung (R8-3-20240909) 2019; 22
Lagerweij (R99-3-20240909) 2017; 20
Alban (R101-3-20240909) 2018; 3
Parmigiani (R69-3-20240909) 2021; 15
Spivakov (R14-3-20240909) 2007; 8
Hosono (R46-3-20240909) 2017; 34
Lee (R104-3-20240909) 2018; 9
Kalmar (R21-3-20240909) 2009; 7
Bercury (R42-3-20240909) 2015; 32
Galvao (R45-3-20240909) 2014; 111
Moore (R57-3-20240909) 2011; 89
Capp (R11-3-20240909) 2019; 2019
Gahoi (R65-3-20240909) 2018; 12
Neftel (R33-3-20240909) 2019; 178
Miron (R49-3-20240909) 2017; 101
Hide (R39-3-20240909) 2018; 30
Piperi (R82-3-20240909) 2019; 8
Ormondroyd (R112-3-20240909) 2018; 20
References_xml – volume: 102
  start-page: 94
  year: 2003
  ident: R15-3-20240909
  article-title: Gene expression analysis of purified hematopoietic stem cells and committed progenitors
  publication-title: Blood
  doi: 10.1182/blood-2002-08-2509
  contributor:
    fullname: Terskikh
– volume: 34
  start-page: 120
  year: 2017
  ident: R46-3-20240909
  article-title: Pericytes promote abnormal tumor angiogenesis in a rat RG2 glioma model
  publication-title: Brain Tumor Pathol
  doi: 10.1007/s10014-017-0291-y
  contributor:
    fullname: Hosono
– volume: 46
  start-page: 32
  year: 2019
  ident: R89-3-20240909
  article-title: Quantitative proteomics reveals reduction of endocytic machinery components in gliomas
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.07.039
  contributor:
    fullname: Buser
– volume: 488
  start-page: 13
  year: 2012
  ident: R10-3-20240909
  article-title: Cancer stem cells tracked
  publication-title: Nature
  doi: 10.1038/488013a
  contributor:
    fullname: Baker
– volume: 33
  start-page: 14558
  year: 2013
  ident: R75-3-20240909
  article-title: NG2 cells in white matter but not gray matter proliferate in response to PDGF
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2001-12.2013
  contributor:
    fullname: Hill
– volume: 102
  start-page: 172
  year: 2022
  ident: R83-3-20240909
  article-title: Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment
  publication-title: Lab Invest
  doi: 10.1038/s41374-021-00695-2
  contributor:
    fullname: Innes
– volume: 53
  start-page: e12865
  year: 2020
  ident: R68-3-20240909
  article-title: Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours
  publication-title: Cell Prolif
  doi: 10.1111/cpr.12865
  contributor:
    fullname: Cheng
– volume: 276
  start-page: 161
  year: 2014
  ident: R56-3-20240909
  article-title: White matter astrocytes in health and disease
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2013.10.050
  contributor:
    fullname: Lundgaard
– volume: 19
  start-page: 156
  year: 2018
  ident: R110-3-20240909
  article-title: Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB)
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-018-2157-7
  contributor:
    fullname: Krempel
– volume: 9
  start-page: 1004
  year: 2018
  ident: R51-3-20240909
  article-title: Immune microenvironment in glioblastoma subtypes
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.01004
  contributor:
    fullname: Chen
– volume: 39
  start-page: 1161
  year: 2018
  ident: R37-3-20240909
  article-title: Glioblastoma niches: From the concept to the phenotypical reality
  publication-title: Neurol Sci
  doi: 10.1007/s10072-018-3408-0
  contributor:
    fullname: Schiffer
– volume: 32
  start-page: 76
  year: 2010
  ident: R9-3-20240909
  article-title: A hypothesis: Neural glial cells, neural stem cells and tumor stem cells transform each other depending on the micro-ecological environment
  publication-title: Zhonghua Zhong Liu Za Zhi
  contributor:
    fullname: Huang
– volume: 175
  start-page: 786
  year: 2009
  ident: R55-3-20240909
  article-title: Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2009.081034
  contributor:
    fullname: Barcia
– volume: 111
  start-page: E4214
  year: 2014
  ident: R45-3-20240909
  article-title: Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1414389111
  contributor:
    fullname: Galvao
– volume: 3
  start-page: 391
  year: 2008
  ident: R19-3-20240909
  article-title: Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.07.027
  contributor:
    fullname: Hayashi
– volume: 453
  start-page: 544
  year: 2008
  ident: R16-3-20240909
  article-title: Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
  publication-title: Nature
  doi: 10.1038/nature06965
  contributor:
    fullname: Chang
– volume: 1875
  start-page: 188458
  year: 2021
  ident: R113-3-20240909
  article-title: Pre-clinical tumor models of primary brain tumors: Challenges and opportunities
  publication-title: Biochim Biophys Acta Rev Cancer
  doi: 10.1016/j.bbcan.2020.188458
  contributor:
    fullname: Akter
– volume: 7
  start-page: e1000149
  year: 2009
  ident: R21-3-20240909
  article-title: Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1000149
  contributor:
    fullname: Kalmar
– volume: 20
  start-page: 37
  year: 2018
  ident: R93-3-20240909
  article-title: Dissecting human gliomas by single-cell RNA sequencing
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nox126
  contributor:
    fullname: Tirosh
– volume: 37
  start-page: 630
  year: 2020
  ident: R32-3-20240909
  article-title: The glioma stem cell model in the era of single-cell genomics
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.04.001
  contributor:
    fullname: Suvà
– volume: 549
  start-page: 533
  year: 2017
  ident: R62-3-20240909
  article-title: Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
  publication-title: Nature
  doi: 10.1038/nature24014
  contributor:
    fullname: Venkatesh
– volume: 47
  start-page: 86
  year: 2017
  ident: R43-3-20240909
  article-title: Myelin plasticity and behaviour-connecting the dots
  publication-title: Curr Opin Neurobiol
  doi: 10.1016/j.conb.2017.09.014
  contributor:
    fullname: Kaller
– volume: 13
  start-page: 2637
  year: 2020
  ident: R85-3-20240909
  article-title: Human cytomegalovirus infection enhances invasiveness and migration of glioblastoma cells by epithelial-to-mesenchymal transition
  publication-title: Int J Clin Exp Pathol
  contributor:
    fullname: Zhu
– volume: 36
  start-page: 63
  year: 2019
  ident: R41-3-20240909
  article-title: Novel concept of the border niche: Glioblastoma cells use oligodendrocytes progenitor cells (GAOs) and microglia to acquire stem cell-like features
  publication-title: Brain Tumor Pathol
  doi: 10.1007/s10014-019-00341-2
  contributor:
    fullname: Hide
– volume: 355
  start-page: eaai8478
  year: 2017
  ident: R92-3-20240909
  article-title: Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aai8478
  contributor:
    fullname: Venteicher
– volume: 101
  start-page: 1103
  year: 2017
  ident: R49-3-20240909
  article-title: Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3RI1116-494R
  contributor:
    fullname: Miron
– volume: 12
  start-page: e1700056
  year: 2018
  ident: R65-3-20240909
  article-title: Multi-pronged proteomic analysis to study the glioma pathobiology using cerebrospinal fluid samples
  publication-title: Proteomics Clin Appl
  doi: 10.1002/prca.201700056
  contributor:
    fullname: Gahoi
– volume: 141
  start-page: 95
  year: 2019
  ident: R96-3-20240909
  article-title: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma
  publication-title: J Neurooncol
  doi: 10.1007/s11060-018-03010-0
  contributor:
    fullname: Bagley
– volume: 46
  start-page: 2673
  year: 2019
  ident: R102-3-20240909
  article-title: AI-based applications in hybrid imaging: How to build smart and truly multi-parametric decision models for radiomics
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-019-04414-4
  contributor:
    fullname: Castiglioni
– volume: 20
  start-page: 42
  year: 2018
  ident: R94-3-20240909
  article-title: Single-cell RNA-sequencing in glioma
  publication-title: Curr Oncol Rep
  doi: 10.1007/s11912-018-0673-2
  contributor:
    fullname: Johnson
– volume: 23
  start-page: 7267
  year: 2004
  ident: R7-3-20240909
  article-title: Cancer stem cells in nervous system tumors
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207946
  contributor:
    fullname: Singh
– volume: 19
  start-page: 351
  year: 2018
  ident: R109-3-20240909
  article-title: An infrastructure for precision medicine through analysis of big data
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-018-2300-5
  contributor:
    fullname: Moscatelli
– volume: 10
  start-page: 1636
  year: 2017
  ident: R100-3-20240909
  article-title: Cetuximab-conjugated nanodiamonds drug delivery system for enhanced targeting therapy and 3D Raman imaging
  publication-title: J Biophotonics
  doi: 10.1002/jbio.201700011
  contributor:
    fullname: Li
– volume: 365
  start-page: 174
  year: 2015
  ident: R77-3-20240909
  article-title: Glioma initiating cells contribute to malignant transformation of host glial cells during tumor tissue remodeling via PDGF signaling
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.05.026
  contributor:
    fullname: Chen
– volume: 11
  start-page: 637
  year: 2014
  ident: R17-3-20240909
  article-title: Validation of noise models for single-cell transcriptomics
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2930
  contributor:
    fullname: Grün
– volume: 77
  start-page: 2266
  year: 2017
  ident: R50-3-20240909
  article-title: Cellular and molecular identity of tumor-associated macrophages in glioblastoma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-16-2310
  contributor:
    fullname: Chen
– volume: 1867
  start-page: 118782
  year: 2020
  ident: R84-3-20240909
  article-title: Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment
  publication-title: Biochim Biophys Acta Mol Cell Res
  doi: 10.1016/j.bbamcr.2020.118782
  contributor:
    fullname: Majc
– volume: 20
  start-page: 320
  year: 2018
  ident: R112-3-20240909
  article-title: “Not pathogenic until proven otherwise”: Perspectives of UK clinical genomics professionals toward secondary findings in context of a Genomic Medicine Multidisciplinary Team and the 100,000 Genomes Project
  publication-title: Genet Med
  doi: 10.1038/gim.2017.157
  contributor:
    fullname: Ormondroyd
– volume: 10
  start-page: 105
  year: 2006
  ident: R13-3-20240909
  article-title: Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2005.10.017
  contributor:
    fullname: Meshorer
– volume: 469
  start-page: 314
  year: 2011
  ident: R76-3-20240909
  article-title: Cells of origin in cancer
  publication-title: Nature
  doi: 10.1038/nature09781
  contributor:
    fullname: Visvader
– volume: 8
  start-page: 1398
  year: 2019
  ident: R82-3-20240909
  article-title: Pivotal role of STAT3 in shaping glioblastoma immune microenvironment
  publication-title: Cells
  doi: 10.3390/cells8111398
  contributor:
    fullname: Piperi
– volume: 34
  start-page: 2997
  year: 2015
  ident: R79-3-20240909
  article-title: Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4281
  contributor:
    fullname: Dai
– volume: 13
  start-page: 877
  year: 2021
  ident: R34-3-20240909
  article-title: Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v13.i7.877
  contributor:
    fullname: Zhang
– volume: 502
  start-page: 489
  year: 2013
  ident: R28-3-20240909
  article-title: The nexus of chromatin regulation and intermediary metabolism
  publication-title: Nature
  doi: 10.1038/nature12752
  contributor:
    fullname: Gut
– volume: 115
  start-page: E2970
  year: 2018
  ident: R105-3-20240909
  article-title: Predicting cancer outcomes from histology and genomics using convolutional networks
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1717139115
  contributor:
    fullname: Mobadersany
– volume: 87
  start-page: 3390
  year: 2009
  ident: R74-3-20240909
  article-title: Neonatal and adult O4(+) oligodendrocyte lineage cells display different growth factor responses and different gene expression patterns
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.22065
  contributor:
    fullname: Lin
– volume: 4
  start-page: e1000217
  year: 2008
  ident: R111-3-20240909
  article-title: Inferring pathway activity toward precise disease classification
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1000217
  contributor:
    fullname: Lee
– volume: 2019
  start-page: 5189232
  year: 2019
  ident: R11-3-20240909
  article-title: Cancer stem cells: From historical roots to a new perspective
  publication-title: J Oncol
  doi: 10.1155/2019/5189232
  contributor:
    fullname: Capp
– volume: 2
  start-page: 437
  year: 2008
  ident: R12-3-20240909
  article-title: Global transcription in pluripotent embryonic stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.03.021
  contributor:
    fullname: Efroni
– volume: 6
  start-page: 247ra101
  year: 2014
  ident: R63-3-20240909
  article-title: Hematogenous dissemination of glioblastoma multiforme
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3009095
  contributor:
    fullname: Müller
– volume: 19
  start-page: 1298
  year: 2017
  ident: R29-3-20240909
  article-title: The impact of cellular metabolism on chromatin dynamics and epigenetics
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3629
  contributor:
    fullname: Reid
– volume: 74
  start-page: 2152
  year: 2014
  ident: R64-3-20240909
  article-title: Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-0813
  contributor:
    fullname: Macarthur
– volume: 7
  start-page: e32453
  year: 2012
  ident: R54-3-20240909
  article-title: Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0032453
  contributor:
    fullname: Katz
– volume: 2017
  start-page: 9634172
  year: 2017
  ident: R38-3-20240909
  article-title: Contribution of the microenvironmental niche to glioblastoma heterogeneity
  publication-title: Biomed Res Int
  doi: 10.1155/2017/9634172
  contributor:
    fullname: Ho
– volume: 48
  start-page: e12772
  year: 2022
  ident: R31-3-20240909
  article-title: Tumour-associated CD204+microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin-6-enriched inflammatory profile in glioblastoma
  publication-title: Neuropathol Appl Neurobiol
  doi: 10.1111/nan.12772
  contributor:
    fullname: Sørensen
– volume: 78
  start-page: 6632
  year: 2018
  ident: R67-3-20240909
  article-title: Circulating glioma cells exhibit stem cell-like properties
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-0650
  contributor:
    fullname: Liu
– volume: 146
  start-page: 209
  year: 2011
  ident: R44-3-20240909
  article-title: Mosaic analysis with double markers reveals tumor cell of origin in glioma
  publication-title: Cell
  doi: 10.1016/j.cell.2011.06.014
  contributor:
    fullname: Liu
– volume: 161
  start-page: 803
  year: 2015
  ident: R61-3-20240909
  article-title: Neuronal activity promotes glioma growth through neuroligin-3 secretion
  publication-title: Cell
  doi: 10.1016/j.cell.2015.04.012
  contributor:
    fullname: Venkatesh
– volume: 30
  start-page: 94
  year: 2018
  ident: R39-3-20240909
  article-title: Oligodendrocyte progenitor cells and macrophages/microglia produce glioma stem cell niches at the tumor border
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2018.02.024
  contributor:
    fullname: Hide
– volume: 211
  start-page: 103578
  year: 2020
  ident: R91-3-20240909
  article-title: Integrated proteomic and metabolomic profiling the global response of rat glioma model by temozolomide treatment
  publication-title: J Proteomics
  doi: 10.1016/j.jprot.2019.103578
  contributor:
    fullname: Li
– volume: 25
  start-page: 99
  year: 2018
  ident: R107-3-20240909
  article-title: Graph-based semi-supervised learning with genomic data integration using condition-responsive genes applied to phenotype classification
  publication-title: J Am Med Inform Assoc
  doi: 10.1093/jamia/ocx032
  contributor:
    fullname: Doostparast Torshizi
– volume: 24
  start-page: 229
  year: 2022
  ident: R30-3-20240909
  article-title: Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noab175
  contributor:
    fullname: Sharma
– volume: 12
  start-page: e201900136
  year: 2019
  ident: R98-3-20240909
  article-title: Quantitative assessment of microenvironment characteristics and metabolic activity in glioma via multiphoton microscopy
  publication-title: J Biophotonics
  doi: 10.1002/jbio.201900136
  contributor:
    fullname: Fang
– volume: 58
  start-page: 2634
  year: 2021
  ident: R22-3-20240909
  article-title: SOX1 is a backup gene for brain neurons and glioma stem cell protection and proliferation
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-020-02240-6
  contributor:
    fullname: Kanwore
– volume: 31
  start-page: 149
  year: 2006
  ident: R47-3-20240909
  article-title: Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2005.10.006
  contributor:
    fullname: Butovsky
– volume: 67
  start-page: 779
  year: 2019
  ident: R53-3-20240909
  article-title: Astrocytes, the rising stars of the glioblastoma microenvironment
  publication-title: Glia
  doi: 10.1002/glia.23520
  contributor:
    fullname: Brandao
– volume: 31
  start-page: 207
  year: 2012
  ident: R4-3-20240909
  article-title: Expression of miR-125b in the new, highly invasive glioma stem cell and progenitor cell line SU3
  publication-title: Chin J Cancer
  doi: 10.5732/cjc.011.10336
  contributor:
    fullname: Wan
– volume: 5
  start-page: 429
  year: 2013
  ident: R24-3-20240909
  article-title: Effects of the in vitro manipulation of stem cells: Epigenetic mechanisms as mediators of induced metabolic fluctuations
  publication-title: Epigenomics
  doi: 10.2217/epi.13.35
  contributor:
    fullname: Paldi
– volume: 7
  start-page: 651
  year: 2010
  ident: R26-3-20240909
  article-title: Reprogramming of human primary somatic cells by OCT4 and chemical compounds
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.11.015
  contributor:
    fullname: Zhu
– volume: 22
  start-page: 1951
  year: 2019
  ident: R8-3-20240909
  article-title: Emerging intersections between neuroscience and glioma biology
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-019-0540-y
  contributor:
    fullname: Jung
– volume: 111
  start-page: 3626
  year: 2020
  ident: R81-3-20240909
  article-title: Novel enhanced GFP-positive congenic inbred strain establishment and application of tumor-bearing nude mouse model
  publication-title: Cancer Sci
  doi: 10.1111/cas.14545
  contributor:
    fullname: Lan
– volume: 450
  start-page: 1230
  year: 2007
  ident: R18-3-20240909
  article-title: Nanog safeguards pluripotency and mediates germline development
  publication-title: Nature
  doi: 10.1038/nature06403
  contributor:
    fullname: Chambers
– volume: 9
  start-page: 2924
  year: 2018
  ident: R86-3-20240909
  article-title: Cancer stem cells and immunosuppressive microenvironment in glioma
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.02924
  contributor:
    fullname: Ma
– volume: 34
  start-page: 2231
  year: 2014
  ident: R48-3-20240909
  article-title: Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1619-13.2014
  contributor:
    fullname: Shigemoto-Mogami
– volume: 10
  start-page: 60
  year: 2018
  ident: R106-3-20240909
  article-title: Integrative omics analyses broaden treatment targets in human cancer
  publication-title: Genome Med
  doi: 10.1186/s13073-018-0564-z
  contributor:
    fullname: Sengupta
– volume: 9
  start-page: 306
  year: 2018
  ident: R60-3-20240909
  article-title: Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-02719-2
  contributor:
    fullname: Mitew
– volume: 142
  start-page: 847
  year: 2019
  ident: R88-3-20240909
  article-title: The landscape of the mesenchymal signature in brain tumours
  publication-title: Brain
  doi: 10.1093/brain/awz044
  contributor:
    fullname: Behnan
– volume: 432
  start-page: 396
  year: 2004
  ident: R1-3-20240909
  article-title: Identification of human brain tumour initiating cells
  publication-title: Nature
  doi: 10.1038/nature03128
  contributor:
    fullname: Singh
– volume: 19
  start-page: 422
  year: 2019
  ident: R87-3-20240909
  article-title: A microfluidic platform utilizing anchored water-in-oil-in-water double emulsions to create a niche for analyzing single non-adherent cells
  publication-title: Lab Chip
  doi: 10.1039/C8LC01130C
  contributor:
    fullname: Cai
– volume: 20
  start-page: 533
  year: 2017
  ident: R99-3-20240909
  article-title: Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment
  publication-title: Angiogenesis
  doi: 10.1007/s10456-017-9565-6
  contributor:
    fullname: Lagerweij
– volume: 77
  start-page: 873
  year: 2013
  ident: R72-3-20240909
  article-title: Oligodendrocyte dynamics in the healthy adult CNS: Evidence for myelin remodeling
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.006
  contributor:
    fullname: Young
– volume: 178
  start-page: 835
  year: 2019
  ident: R33-3-20240909
  article-title: An integrative model of cellular states, plasticity, and genetics for glioblastoma
  publication-title: Cell
  doi: 10.1016/j.cell.2019.06.024
  contributor:
    fullname: Neftel
– volume: 28
  start-page: 1014
  year: 2018
  ident: R25-3-20240909
  article-title: Metabolic and mechanical cues regulating pluripotent stem cell fate
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2018.09.005
  contributor:
    fullname: Perestrelo
– volume: 12
  start-page: e201900006
  year: 2019
  ident: R103-3-20240909
  article-title: Automatic and label-free identification of blood vessels in gliomas using the combination of multiphoton microscopy and image analysis
  publication-title: J Biophotonics
  doi: 10.1002/jbio.201900006
  contributor:
    fullname: Fang
– volume: 11
  start-page: 2435
  year: 2015
  ident: R78-3-20240909
  article-title: Experimental research of host macrophage canceration induced by glioma stem progenitor cells
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2014.3032
  contributor:
    fullname: Wang
– volume: 22
  start-page: 8553
  year: 2002
  ident: R73-3-20240909
  article-title: Cyclin-dependent kinase-2 controls oligodendrocyte progenitor cell cycle progression and is downregulated in adult oligodendrocyte progenitors
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.22-19-08553.2002
  contributor:
    fullname: Belachew
– volume: 18
  start-page: 2342
  year: 2017
  ident: R36-3-20240909
  article-title: The molecular and phenotypic basis of the glioma invasive perivascular niche
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18112342
  contributor:
    fullname: Diksin
– volume: 3
  start-page: 122264
  year: 2018
  ident: R101-3-20240909
  article-title: Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.122264
  contributor:
    fullname: Alban
– volume: 8
  start-page: 304
  year: 2008
  ident: R3-3-20240909
  article-title: Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-8-304
  contributor:
    fullname: Huang
– volume: 9
  start-page: 42
  year: 2018
  ident: R104-3-20240909
  article-title: A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-02465-5
  contributor:
    fullname: Lee
– volume: 53
  start-page: 764
  year: 2013
  ident: R40-3-20240909
  article-title: New treatment strategies to eradicate cancer stem cells and niches in glioblastoma
  publication-title: Neurol Med Chir (Tokyo
  doi: 10.2176/nmc.ra2013-0207
  contributor:
    fullname: Hide
– volume: 15
  start-page: 709917
  year: 2021
  ident: R69-3-20240909
  article-title: Old stars and new players in the brain tumor microenvironment
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2021.709917
  contributor:
    fullname: Parmigiani
– volume: 344
  start-page: 1252304
  year: 2014
  ident: R59-3-20240909
  article-title: Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
  publication-title: Science
  doi: 10.1126/science.1252304
  contributor:
    fullname: Gibson
– volume: 16
  start-page: 73
  year: 2020
  ident: R90-3-20240909
  article-title: Proteomics and molecular network analyses reveal that the interaction between the TAT-DCF1 peptide and TAF6 induces an antitumor effect in glioma cells
  publication-title: Mol Omics
  doi: 10.1039/C9MO00068B
  contributor:
    fullname: Wang
– volume: 28
  start-page: 190
  year: 2019
  ident: R108-3-20240909
  article-title: Contributions from the 2018 literature on bioinformatics and translational informatics
  publication-title: Yearb Med Inform
  doi: 10.1055/s-0039-1677945
  contributor:
    fullname: Smaïl-Tabbone
– volume: 12
  start-page: 1918
  year: 2017
  ident: R5-3-20240909
  article-title: Research on human glioma stem cells in China
  publication-title: Neural Regen Res
  doi: 10.4103/1673-5374.219055
  contributor:
    fullname: Zhao
– volume: 8
  start-page: 744
  year: 2012
  ident: R20-3-20240909
  article-title: Dissecting ensemble networks in ES cell populations reveals micro-heterogeneity underlying pluripotency
  publication-title: Mol Biosyst
  doi: 10.1039/c1mb05398a
  contributor:
    fullname: Trott
– volume: 11
  start-page: 5
  year: 2018
  ident: R35-3-20240909
  article-title: Glioblastoma: Microenvironment and niche concept
  publication-title: Cancers (Basel
  doi: 10.3390/cancers11010005
  contributor:
    fullname: Schiffer
– volume: 5
  start-page: 57
  year: 2009
  ident: R71-3-20240909
  article-title: Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
  publication-title: Neuron Glia Biol
  doi: 10.1017/S1740925X09990354
  contributor:
    fullname: Psachoulia
– volume: 89
  start-page: 13
  year: 2011
  ident: R57-3-20240909
  article-title: How factors secreted from astrocytes impact myelin repair
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.22482
  contributor:
    fullname: Moore
– volume: 55
  start-page: 6927
  year: 2018
  ident: R52-3-20240909
  article-title: Reactive astrocytes in glioblastoma multiforme
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-018-0880-8
  contributor:
    fullname: Guan
– volume: 65
  start-page: 9843
  year: 2005
  ident: R66-3-20240909
  article-title: Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-1842
  contributor:
    fullname: Dasgupta
– volume: 16
  start-page: 909
  year: 2006
  ident: R2-3-20240909
  article-title: Differentiation profile of brain tumor stem cells: A comparative study with neural stem cells
  publication-title: Cell Res
  doi: 10.1038/sj.cr.7310104
  contributor:
    fullname: Zhang
– volume: 32
  start-page: 447
  year: 2015
  ident: R42-3-20240909
  article-title: Dynamics and mechanisms of CNS myelination
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2015.01.016
  contributor:
    fullname: Bercury
– volume: 5
  start-page: 237
  year: 2009
  ident: R27-3-20240909
  article-title: Hypoxia enhances the generation of induced pluripotent stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.08.001
  contributor:
    fullname: Yoshida
– volume: 13
  start-page: 1
  year: 2022
  ident: R23-3-20240909
  article-title: HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
  publication-title: J Cancer
  doi: 10.7150/jca.54402
  contributor:
    fullname: Wang
– volume: 2
  start-page: 1636
  year: 2016
  ident: R97-3-20240909
  article-title: The potential of radiomic-based phenotyping in precision medicine: A review
  publication-title: JAMA Oncol
  doi: 10.1001/jamaoncol.2016.2631
  contributor:
    fullname: Aerts
– volume: 341
  start-page: 2
  year: 2013
  ident: R70-3-20240909
  article-title: Overview: Cellular plasticity, cancer stem cells and metastasis
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2013.06.020
  contributor:
    fullname: Elshamy
– volume: 5
  start-page: 805
  year: 2016
  ident: R80-3-20240909
  article-title: STAT3 signaling pathway regulates glioma stem cells induced host macrophage malignance
  publication-title: Transl Cancer Res
  doi: 10.21037/tcr.2016.12.05
  contributor:
    fullname: Lei
– volume: 7
  start-page: 155
  year: 2019
  ident: R95-3-20240909
  article-title: Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-019-0819-y
  contributor:
    fullname: Saurty-Seerunghen
– volume: 8
  start-page: 263
  year: 2007
  ident: R14-3-20240909
  article-title: Epigenetic signatures of stem-cell identity
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2046
  contributor:
    fullname: Spivakov
– volume: 16
  start-page: 580
  year: 2013
  ident: R58-3-20240909
  article-title: Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3371
  contributor:
    fullname: Bardehle
SSID ssib046627157
ssj0002246031
ssib044737797
Score 2.2186718
Snippet Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor...
SourceID doaj
gale
crossref
wolterskluwer
SourceType Open Website
Aggregation Database
Publisher
StartPage 12
SubjectTerms Cancer
Chemotherapy
cytomegalovirus infects glioma
embryonic stem cell
epithelial-stromal transformation of glioma
glioblastoma
glioma
glioma microenvironment
glioma stem cell niche
glioma stem cells
Gliomas
mesenchymal stem cells
remodeling of glioma microenvironment
Stem cells
SummonAdditionalLinks – databaseName: Medknow Open Access Medical Journals
  dbid: W3E
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Ri9QwEA7H-SKInKi4ekoeBB-keEnTprniwyp3HoI-ebj44JA06Xmn28reruK_dyZJj90X32ShC7tpms6Xmcy0mW8Ye15q521tdWFx9SpUsKKw3oTCyK7X2gRTR-7ODx_rs3P1flEt9tiUWkW7Kq8uflyOSxvNdBZfTOqKSiGrxmC4I8r2D84EDIilbLMeV20eapt0Ucg2WXRhWrtBX3T9-su3TRvJiDDIv0XxGBV7-FyeTDNQER36xD5zFclhFJVhpgp104VT5o0SR-WrPND0BRVIubO6xSIAN6b-zu-R3n9ff4_b37cWsdMDdjd7n3ye7vce2wvDffb1XeyZE6Uzpwf519wOnsdXCHxJG_a2suGO-ZwPdpX4wnlKfOHjwD3aVVwF05lbzvA4PGDnpyef3p4VuexC0aF39KsQurHeOX3kTBBe152qfFn2eLSi6RyChx-UTQiuUQEdCO90Gah4qLGe-N4esv1hHMIjxr3C6K9XlJMolKsDNsB-hXS-chiTixl7OYkLfiZ2DcCohIQLWapbwp2xNyTRm5bEjB1_GFcXkGcKNF5gUCis9t4otJ626XonQ9XUwfe90TP2gvAA0l8UR2dzGgIOmJiwYF6Tx6ZLrWbscKcl6l238_diB1FYpvzFf9wACAkJUiBIIUIKCAxESGGC9PH_6_oJu006kx4iHbL99WoTnqJbtXbPoib8BVRBKak
  priority: 102
  providerName: Wolters Kluwer Health
Title Glioma stem cells and their microenvironment: A narrative review on docking and transformation
URI http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=1;spage=12;epage=19;aulast=Zhu;type=0
https://doaj.org/article/8d12611a7dd94376a8cfb2e586edff97
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PS-UwEA7iSRBRVvGpu-QgeFi6vrRp03h7ylNZ0JPiO-2QNKn447Wi7nrzb9-ZpO_Rd9GLFFJo09LMN-nMtJlvGNvPlHWmMCoxaL0S6Y1IjNM-0WlVK6W9LgJ358VlcX4tf0_ySa_UF60Ji_TAUXCHpRPo5AujnNMSZ4Mpq9qmPi8L7-paxzzyoe4FU6hJUioi0psbVkk05zNWmftA-iKpvDJVnstLjfGTyGJGjRTD7PD28a6dml9xBzmk6YLVCuT-81f46ltL_7VfHsKy9p5xOl1na51XyUdxNBtsyTff2J-zcGdOVM2cPtC_cNM4Hn4N8CktxOtluR3xEW_Mc-QB5zGhhbcNd_i-ROsWr-w5uW2zya5Px1cn50lXTiGp0Ov5lwhVGmetGlrthVNFJXOXZTW2RpSVRVBwQ9l4b0vp0TFwVmWeioJq44jHbYstN23jtxl3EqO6WlKuoZC28NgB7ytS63KLsbYYsJ8zccFTZM0AjDZIuNBJtSfcATsmic57EuN1OIB6AJ0ewGd6MGAHhAfQvERxVKZLL8AHJoYrGBXkiaFayAHbW-iJ86laOD1ZQBSmMS_xgwGASCFCCgQpBEgBgYEAKcwg3fmKge6ylZRSMMJnoD22_Pr8139Hx-jV_ghzANuL9zG2N9n4P734D_8
link.rule.ids 315,783,787,867,2109,27470,27936,27937
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glioma+stem+cells+and+their+microenvironment%3A+A+narrative+review+on+docking+and+transformation&rft.jtitle=Glioma&rft.au=Zhu%2C+Wenyu&rft.au=Chen%2C+Hua&rft.au=Yan%2C+Ke&rft.au=Wu%2C+Jie&rft.date=2022-01-01&rft.pub=Medknow+Publications+and+Media+Pvt.+Ltd&rft.issn=2589-6113&rft.volume=5&rft.issue=1&rft.spage=12&rft_id=info:doi/10.4103%2Fglioma.glioma_5_22&rft.externalDocID=A699377374
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2589-6113&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2589-6113&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2589-6113&client=summon