Glioma stem cells and their microenvironment: A narrative review on docking and transformation

• Published in: Glioma Vol. 5; no. 1; pp. 12 - 19
• Main Authors: Zhu, Wenyu, Chen, Hua, Yan, Ke, Wu, Jie, Zhao, Yaodong, Huang, Qiang
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer - Medknow Publications 01.01.2022; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Cancer; Chemotherapy; cytomegalovirus infects glioma; embryonic stem cell; epithelial-stromal transformation of glioma; glioblastoma; glioma; glioma microenvironment; glioma stem cell niche; glioma stem cells; Gliomas; mesenchymal stem cells; remodeling of glioma microenvironment; Stem cells; epithelial-stromal transformation of glioma; glioblastoma; Cytomegalovirus infects glioma; embryonic stem cell; glioma stem cell niche; glioma microenvironment; mesenchymal stem cells; glioma; glioma stem cells; remodeling of glioma microenvironment
• ISSN: 2589-6113; 2589-6121
• DOI: 10.4103/glioma.glioma_5_22

Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor microenvironment (TME) transformation: (1) Because GSCs also have heterogeneity, they are a state, not an entity. (2) The importance of the border niche among many tumor niches is emphasized because it is a shelter for tumor resistance to radiotherapy and chemotherapy. (3) The plasticity of GSCs and TME cells allows TME cells to become GSC-initiating cells. (4) Future development will entail a close interaction between high-throughput molecular biology and artificial intelligence. In this review, we summarize recent advances in GSCs and their microenvironment from the following three aspects: the constantly updated of concept of stem cells, the concept of TME and niche, and the plasticity of GSCs and TME cells.