Neuroendocrine Carcinoma of the Colon: Report of 3 Cases

Neuroendocrine carcinomas were diagnosed in 3 of 1, 021 patients who had colon cancers removed from October 1997 to September 2002 for an incidence of 0.29%. Patients were 2 men and 1 woman, 59 to 70 years of age (median, 65.3 years). Treatment involved: 2 right hemicolectomies and 1 sigmoidectomy....

Full description

Saved in:
Bibliographic Details
Published inNippon Shokaki Geka Gakkai zasshi Vol. 36; no. 6; pp. 503 - 508
Main Authors Kouchi, Yasuhiro, Jimbou, Mitsutaka, Shigeta, Masatoshi, Inokuchi, Tomohiro, Fujita, Yuji, Miyahara, Makoto, Kubo, Hidefumi, Hasegawa, Hiroyasu, Miyashita, Hiroshi
Format Journal Article
LanguageJapanese
Published The Japanese Society of Gastroenterological Surgery 2003
Subjects
colon cancer
neuroendocrine carcinoma
Online AccessGet full text

Cover

More Information
Summary:Neuroendocrine carcinomas were diagnosed in 3 of 1, 021 patients who had colon cancers removed from October 1997 to September 2002 for an incidence of 0.29%. Patients were 2 men and 1 woman, 59 to 70 years of age (median, 65.3 years). Treatment involved: 2 right hemicolectomies and 1 sigmoidectomy. Colonic carcinoma is more likely to be malignant in lymphatic, vascular and liver metastases and the prognosis is dismal. These tumors showed light microscopic and immunohistochemical evidence of adenocarcinomatous areas, and neuroendocrine differentiation demonstrated by positive neuronspecific enolase (NSE), synaptophysin, and chromogranin-A staining. Neuroendocrine carcinoma has the least favorable prognosis and surgical treatment alone cannot provide a cure. When undifferentiated carcinoma or poorly differentiated adenocarcinoma is indicated for colorectal lesions at biopsy, aggressive exploration entertaining a possible existence of the disease is essential. Effective multimodal therapy should include operation and chemotherapy.
ISSN:0386-9768
1348-9372
DOI:10.5833/jjgs.36.503