A genome-wide allelotype study of primary and corresponding recurrent glioblastoma multiforme in one patient

Glioblastoma multiforme (GBM) is the most common type of primary malignant brain tumor. Although comprehensive therapeutic measures are available, recurrence is very frequent and the prognosis of GBM remains dismal. To date, little is known about the molecular pathogenesis associated with GBM recurr...

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Bibliographic Details
Published inChinese medical journal Vol. 117; no. 3; pp. 456 - 458
Main Author 胡杰 江澄川 吴浩强 彭颂先 唐婉君 陈商群
Format Journal Article
LanguageEnglish
Published China Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai 200040,China%Department of Anatomical and Cellular Pathology,Chinese University of Hong Kong,Shatin,N.T.,Hong Kong,China 01.03.2004
Subjects
Adult
Brain Neoplasms - genetics
DNA, Neoplasm - analysis
Female
Genome
Glioblastoma - genetics
Humans
Loss of Heterozygosity
Microsatellite Repeats
Neoplasm Recurrence, Local - genetics
Polymerase Chain Reaction
多发性肿瘤
恶性胶质瘤
病理特点
等位基因
综合疗法
loss of heterozygosity
glioblastoma
genes,tumor suppressor
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Summary:Glioblastoma multiforme (GBM) is the most common type of primary malignant brain tumor. Although comprehensive therapeutic measures are available, recurrence is very frequent and the prognosis of GBM remains dismal. To date, little is known about the molecular pathogenesis associated with GBM recurrence.
Bibliography:R739.41
11-2154/R
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ISSN:0366-6999
2542-5641