Cu( i )-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2- a ]pyridines

An iodine/CuI mediated double oxidative C–H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2- a ]pyridines ( 3e...

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Published inRSC advances Vol. 6; no. 44; pp. 38033 - 38036
Main Authors Dheer, Divya, Reddy, K. Ranjith, Rath, Santosh K., Sangwan, P. L., Das, Parthasarthi, Shankar, Ravi
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Drugs
Ingredients
Iodine
Methodology
Pharmaceuticals
Synthesis
Synthesis (chemistry)
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Summary:An iodine/CuI mediated double oxidative C–H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2- a ]pyridines ( 3e ) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA02953A