Light-triggered strand exchange reaction using the change in the hydrogen bonding pattern of a nucleobase analogue

A light-triggered strand exchange reaction was developed using the change in the hydrogen-donor-acceptor pattern of a nucleobase analogue. We demonstrated that a new light-responsive nucleobase analogue derived from 4-hydroxy-2-mercaptobenzimidazole (SB super(NV)) preferentially recognized guanine b...

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Published inChemical science (Cambridge) Vol. 5; no. 2; pp. 744 - 750
Main Authors Morihiro, Kunihiko, Kodama, Tetsuya, Waki, Reiko, Obika, Satoshi
Format Journal Article
LanguageEnglish
Published 01.01.2014
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Summary:A light-triggered strand exchange reaction was developed using the change in the hydrogen-donor-acceptor pattern of a nucleobase analogue. We demonstrated that a new light-responsive nucleobase analogue derived from 4-hydroxy-2-mercaptobenzimidazole (SB super(NV)) preferentially recognized guanine before photoirradiation and adenine after photoirradiation in duplexes. By using oligodeoxynucleotides modified with SB super(NV), a light-triggered strand exchange reaction targeting different mRNA fragment sequences was achieved. These results indicate that SB super(NV) could be a powerful material for manipulating a nucleic acid assembly in a spatially and temporally controlled manner.
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ISSN:2041-6520
2041-6539
DOI:10.1039/C3SC51987B