Enhanced oral absorption of saquinavir mediated by PEGylated solid lipid nanoparticles

PEGylated solid lipid nanoparticles containing saquinavir were prepared by a solvent diffusion method combined with ionic complexation, and exhibited a higher drug encapsulation efficiency, drug loading capacity and slowed drug release behavior. Moreover, the nanoparticles presented low cytotoxicity...

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Bibliographic Details
Published inRSC advances Vol. 5; no. 50; pp. 40341 - 40347
Main Authors Hu, Xiaoyu, Kang, Xuqi, Ying, Xiaoying, Wang, Lejian, Du, Yongzhong
Format Journal Article
LanguageEnglish
Published 01.01.2015
Subjects
Absorption
Drugs
Efficiency
Encapsulation
Lipids
Nanoparticles
Polyethylene glycol
Toxicity
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Summary:PEGylated solid lipid nanoparticles containing saquinavir were prepared by a solvent diffusion method combined with ionic complexation, and exhibited a higher drug encapsulation efficiency, drug loading capacity and slowed drug release behavior. Moreover, the nanoparticles presented low cytotoxicity, higher transport ability across intestinal epithelial cells, and hence higher relative bioavailability which increased with enhancing of the polyethylene glycol content in the nanoparticles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA05283A