Advancements and challenges of patterning biomolecules with sub-50 nm features

In recent years, the patterning of biomolecules with sub-50 nanometer resolution has enabled fundamental studies on cellular interactions with their environment and the development of densely packed biosensors. To further these efforts, the ability to precisely position multicomponent, single biomol...

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Bibliographic Details
Published inSoft matter Vol. 9; no. 29; pp. 6578 - 6586
Main Authors Tran, Helen, Killops, Kato L., Campos, Luis M.
Format Journal Article
LanguageEnglish
Published 01.01.2013
Subjects
Biomolecules
Biosensors
Cellular
Clusters
Nanostructure
Patterning
Strategy
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Summary:In recent years, the patterning of biomolecules with sub-50 nanometer resolution has enabled fundamental studies on cellular interactions with their environment and the development of densely packed biosensors. To further these efforts, the ability to precisely position multicomponent, single biomolecules and small clusters in various shapes and patterns has emerged as a major challenge. We highlight recent strategies to immobilize biomolecules with sub-50 nanometer resolution, emphasizing the advancements and challenges associated with each approach.
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ISSN:1744-683X
1744-6848
DOI:10.1039/c3sm00149k